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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Tumor localization accuracy for high-precision radiotherapy during active breath-hold
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Tumor localization accuracy for high-precision radiotherapy during active breath-hold

机译：肿瘤定位精度为高精度放射治疗期间的高精度放疗

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Background: Conventionally fractionated and stereotactic body radiation therapy (SBRT) for thoracoab-dominal tumors may utilize breath-hold techniques. However, there are concerns that differential amounts of inspired airflow may result in unplanned tumor dislocation and underdosing. Thus, we investigated tumor localization accuracy associated with lung volume variations during breath-hold treatment via an automated-gating interface. Methods: Twelve patients received breath-hold treatment with the active breathing coordinator (ABC) through an automated-gating interface. All breath-hold volumes were recorded at CT simulation, setup imaging, and during treatment, and analyzed as a function of airflow rate into the ABC. The variation of breath-hold volumes was calculated for each fraction over entire course. Intrafraction target motion related to the breathing variation was investigated based on daily imaging acquired before the breath-hold treatment. Correlation between target location and breath-hold variation was statistically analyzed. Results: The air volume held by the ABC increased as the airflow rate increased on inhalation and decreased on exhalation. The mean range of airflow rate was 0.77 L/s and 0.29 L/s in the conventionally fractionated and SBRT patients, respectively. The maximum air volume difference with respect to the reference volume at the CT simulation was 1.0 L for conventional fractionation and 0.16 L for SBRT. The target dislocation caused by 0.25 L of air volume difference was 6 mm for SBRT. Three patients showed significant correlation between the target location and breath-hold variations. Conclusions: This investigation shows that because variations in the breath-hold volume may cause target dislocation, patient-specific breath-hold setting is required to improve tumor localization accuracy.
机译：背景：传统分级分级和胸腔组肿瘤的立体定向体辐射治疗（SBRT）可利用呼吸保持技术。然而，涉及差异量的受启发量的气流可能导致无计划的肿瘤位错和减少。因此，我们通过自动门控界面在呼吸保持处理期间调查与肺部体积变化相关的肿瘤定位精度。方法：12名患者通过自动门控界面接受有源呼吸协调器（ABC）的呼吸保持处理。在CT模拟，设置成像和治疗期间，记录所有呼吸卷积，并作为气流率的函数分析到ABC中。在整个过程中为每个分数计算呼吸率体积的变化。基于在呼吸治疗前获得的日常成像研究了与呼吸变异相关的腹内目标运动。统计分析目标位置与呼吸变化之间的相关性。结果：ABC持有的空气量随着气流率的增加而增加，呼气下降并减少。在常规分级和SBRT患者中分别在0.77L / s和0.29L / s的平均范围内。对于CT模拟中的参考体积的最大空气体积差为1.0L，用于常规分馏和SBRT的0.16L。 SBRT为0.25L空气体积差引起的目标位错为6mm。三名患者在目标位置与呼吸持有变化之间表现出显着相关性。结论：本研究表明，由于呼吸率体积的变化可能导致目标位错，所以需要特定于患者的呼吸保持设置来提高肿瘤定位精度。

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