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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Palliative radiotherapy for locally advanced non-metastatic head and neck cancer: A systematic review
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Palliative radiotherapy for locally advanced non-metastatic head and neck cancer: A systematic review

机译：用于局部先进的非转移性头颈癌的姑息放疗：系统评价

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Objectives: The objective of this systematic review was to identify and appraise the existing evidence of role of palliative radiotherapy for locally advanced non-metastatic head and neck cancer. Methods: A systematic search of the literature was conducted using Medline, Embase and Cochrane databases and relevant references were included. Results: Literature search revealed a wide variation in dose fractionation regimens. Reported outcomes showed high efficacy and low rate of significant side effects, except in studies utilising higher doses of radiotherapy where higher grade toxicities were seen. Reported median overall survival was in the range of 33-17 months, but most studies reported median survival of around 6 months. Conclusions: The choice of palliative radiotherapy varies significantly. This is in contrast to regimens of curative radiotherapy for locally advanced head and neck cancer, which are well standardised. Given the reported relatively short overall survival of this patient group, an ideal treatment should be of the shortest possible duration whilst ensuring effective palliation and minimal side effects. Future well designed trials are needed to evaluate quality of life and duration of side effects in addition to survival and severity of toxicities in this group of patients. Crown Copyright (C) 2017 Published by Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 126 (2018) 558-567
机译：目标：该系统审查的目的是识别和评估姑息治疗局部晚期的非转移头和颈癌的姑息放疗作用的现有证据。方法：使用Medline，Embase和Cochrane数据库进行文献的系统搜索，并包括相关参考。结果：文献搜索揭示了剂量分馏方案的广泛变化。除了利用较高级别的放射治疗的研究外，报告的结果显示出高疗效和显着副作用的高副作用。报告的中位数总生存率在33-17个月的范围内，但大多数研究报告了6个月的中位生存。结论：姑息放疗的选择显着各异。这与局部晚期头部和颈部癌症的治疗放疗方案形成鲜明对比，这是良好的标准化。鉴于据报道的患者组的总体存活率相对较短，理想的治疗应该是最短的持续时间，同时确保有效的缓和和最小的副作用。除了这群患者中毒性的生存和严重程度之外，还需要未来设计的试验来评估生活质量和副作用的持续时间。皇冠版权（c）2017由elsevier爱尔兰有限公司出版。保留所有权利。放射疗法和肿瘤学126（2018）558-567

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