...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Clinical features and survival outcomes between ascending and descending types of nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: A big-data intelligence platform-based analysis
【24h】

Clinical features and survival outcomes between ascending and descending types of nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: A big-data intelligence platform-based analysis

机译：强度调制放疗时代鼻咽癌升序和降期类型的临床特征和生存结果：基于大数据智能平台的分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: To compare clinical features and survival outcomes in patients with ascending type (type A) and descending type (type D) nasopharyngeal carcinoma (NPC) in the intensity-modulated radiotherapy (IMRT) era. Materials and methods: A total of 5194 patients with type A and type D NPC treated at Sun Yat-sen University Cancer Center were randomly selected. Tumors that were mainly advanced local disease (T3-4 stage) with early stage cervical lymph node involvement (NO-1 stage) were determined as type A, while tumors with advanced lymph node disease (N2-3 stage) but early stage local invasion (Tl-2 stage) were classified as type D NPC. Kaplan-Meier's analysis was used to evaluate survival rates, and log-rank test survival curves were used for comparison. In the multivariate analysis Cox proportional hazard models were developed. Results: There was a larger proportion of type A tumors (82%) than type D tumors (18%). Compared to patients with type A tumors, those with type D tumors had increased likelihood of distant metastasis, regional recurrence, disease recurrence, and death (P< 0.001 for all), however, not for local recurrence (P< 0.001). The HR (hazard ratio) for death following recurrence of disease for type D tumors were 1.6 compared to type A tumors. Multivariate analysis revealed that elevated EBV DNA, elevated lactate dehy-drogenase, alcohol consumption, and no family history of cancer attributed to the development of type D tumors. Annual hazard rate in type A patients increased, peaking at 12-18 months after initial treatment and downward thereafter. Similar trend also occurred in type D during the first 5 years following treatment. Notably, a minor peak was also observed 7-8 years post treatment. Conclusions: In the IMRT era, recurrence patterns differed across tumor types. Type D NPC had a more aggressive clinical course and worse outcomes compared with type A NPC.
机译：目的：在强度调节放疗（IMRT）时代，比较患者升高（类型A）和下降型（D）鼻咽癌（NPC）患者的临床特征和生存结果。材料和方法：随机选择共有5194例A型A型和A型D NPC患者。主要是晚期宫颈淋巴结受累（NO-1阶段）的晚期局部疾病（T3-4阶段）的肿瘤被确定为A型，而具有晚期淋巴结疾病（N2-3阶段）但早期局部入侵的肿瘤（TL-2阶段）被分类为D NPC型。 Kaplan-Meier的分析用于评估存活率，并且使用对数级测试存活曲线进行比较。在多变量分析中，开发了COX比例危险模型。结果：比D型肿瘤（82％）造成较大的比例（82％）（18％）。与患有肿瘤的患者相比，D型肿瘤的患者增加了远处转移，区域复发，疾病复发和死亡的可能性（所有疾病，疾病，疾病的死亡（P <0.001），而不是局部复发（P <0.001）。与类型肿瘤的疾病复发后，死亡后的人力资源（危险比）为1.6。多变量分析显示，EBV DNA升高，乳酸缺血酶，醇消耗，癌症的血液消耗，没有归因于D型肿瘤的发展。患者的年度危险率在初始治疗后12-18个月内增加，此后在12-18个月后达到峰值。在治疗后的前5年期间，D型也发生了类似的趋势。值得注意的是，治疗后7-8岁也观察到次要峰。结论：在IMRT时代，肿瘤类型的复发模式不同。与类型NPC相比，D NPC型具有更具侵略性的临床课程和更糟糕的结果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号