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CRYSTALLINE RETINOPATHY AND RETINAL VASCULOPATHY IN CALCIFIC UREMIC ARTERIOLOPATHY (CALCIPHYLAXIS)

机译:钙化尿道动脉神经病变的结晶视网膜病变与视网膜血管病变(钙吡咯)

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摘要

Purpose: To report the posterior segment and retina! vascular manifestations of calcific uremic arteriolopathy (calciphylaxis). Clinical findings are correlated with multimodal imaging results. Methods: Observational case report. Results: A 65-year-old white woman on hemodialysis was referred for assessment of poor vision bilaterally. Clinical examination demonstrated a crystalline retinopathy with stigma of previous retinal arterial occlusion. Fluorescein angiography revealed delayed retinal arterial filling bilaterally, sheathing of vessels, and peripheral nonperfusion. The crystals were hyperautofluorescent. Spectral domain and enhanced depth imaging optical coherence tomography localized the crystals within the retina with a predilection for the retinal arterial vasculature. The choriocapillaris was not involved. Two years prior, the patient developed necrotic skin lesions which were biopsied and confirmed the diagnosis of calciphylaxis. Conclusion: Calcific uremic arteriolopathy is an extremely rare cause of thrombogenic microangiopathy in end-stage renal disease patients. Retinal arterial occlusion appears to be a rare but significant cause of visual loss in this disease and is likely to be consequent to crystalline deposition in the retinal vasculature.
机译:目的:报告后部和视网膜!钙化尿道动脉瘤的血管表现(Calciphylaxis)。临床发现与多峰成像结果相关。方法:观察病例报告。结果:提到了一名65岁的白人女性,用于评估双方视力差的评估。临床检查证明了先前视网膜动脉闭塞的颗粒状视网膜病变。荧光素血管造影显示延迟视网膜动脉填充双侧,血管护套和外周非灌注。晶体是高荧光。光谱结构域和增强深度成像光学相干断层扫描局部地利用视网膜动脉脉管系统的偏移来定位视网膜内的晶体。芝麻皮卡里斯没有参与其中。两年前,患者发育了被活检的坏死皮肤病,并确认了钙糊糊的诊断。结论:钙化尿道动脉神经病症是末期肾病患者血栓形成微观神经病变的极其罕见的原因。视网膜动脉闭塞似乎是这种疾病视觉损失的罕见但重要原因,因此可能会导致视网膜脉管系统中的结晶沉积。

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