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首页> 外文期刊>Reviews in medical virology >Rotavirus virus‐like particles (RV‐VLPs) vaccines: An update
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Rotavirus virus‐like particles (RV‐VLPs) vaccines: An update

机译：RotaVirus病毒样颗粒（RV-VLPS）疫苗：更新

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Summary Rotaviruses (RVs) cause over 0.2 million deaths annually and are reported to be the foremost cause of gastroenteritis in infants and children worldwide. Vaccination against RVs is the most successful and unsurpassed strategy to combat infection to date. Although the 2 current vaccines, Rotarix and RotaTeq, have dramatically reduced the disease burden, still there is a need for new vaccines. In this context, RV virus‐like particles (RV‐VLPs) represent potential vaccine candidates as they are noninfectious and effective nonreplicating immunogens that may reduce the risk of side effects related to the conventional vaccines. VLPs being conformationally similar to the parent virus are highly immunogenic and hence provide enhanced protection and better serotype coverage. In this review, we have highlighted the various advantages and the implications of RV‐VLPs, discussed the general strategies employed for their production, and talked about the recent developments made in this regard. Overall, the review emphasizes the probable utility of RV‐VLPs in eradicating the highly widespread RVs.
机译：发明内容每年造成120万人死亡人数，据报道是全世界婴幼儿胃肠炎最重要的原因。对RV的疫苗接种是最达到感染的最成功和无与伦比的策略。虽然2个当前疫苗，滚石和旋转Q，大大降低了疾病负担，但仍然需要新的疫苗。在这种情况下，RV病毒样颗粒（RV-VLP）代表潜在的疫苗候选者，因为它们是非缺浮和有效的非重种免疫原，其可以降低与常规疫苗相关的副作用的风险。与母体病毒构象相似的VLP是高度免疫原性的，因此提供增强的保护和更好的血清型覆盖。在本综述中，我们强调了RV-VLP的各种优势和含义，讨论了其生产的一般策略，并谈到了这方面的最新发展。总体而言，审查强调RV-VLP的可能效用在消除高度广泛的RV方面。

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