Thermal Behavoiur of Valsartan Active Substance and in Pharmaceutical Products

Tita Ioana Cristina; Tita Bogdan; Toma Claudia Crina; Marian Eleonora; Vicas Laura

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Thermal Behavoiur of Valsartan Active Substance and in Pharmaceutical Products

机译：Valsartan活性物质和药物产品的热行为

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TG/DTG and DSC curves provide important information regarding the physical properties of the pharmaceutical compounds (stability, compatibility, polymorphism, kinetic analysis, phase transitions etc). The thermal behaviour of valsartan was studied under dynamic nitrogen atmosphere, in comparison with pharmaceutical products containing the corresponding active substances. Also, the FT-IR spectra and X-ray diffactogram of the same samples were recorded. The main conclusion of this comparative study was that TG/DTG and DSC assays along with FT-IR spectra and X-ray diffractograms provide credible data for differences between active substance and pharmaceutical forms.

机译：TG / DTG和DSC曲线提供了有关药物化合物的物理性质的重要信息（稳定性，相容性，多态性，动力学分析，相转变等）。与含有相应活性物质的药物产品相比，在动态氮气氛下研究了缬沙坦的热行为。此外，记录了同一样品的FT-IR光谱和X射线Diffactogram。该比较研究的主要结论是Tg / DTG和DSC测定以及FT-IR光谱和X射线衍射图提供了可信地具有可信的数据，用于有源物质和药物形式之间的差异。

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来源
《Revista de Chimie》 |2017年第10期|共4页
作者
Tita Ioana Cristina; Tita Bogdan; Toma Claudia Crina; Marian Eleonora; Vicas Laura;
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作者单位

Carol Davila Univ Med &

Pharm Fac Pharm 6 Traian Vuia Str Bucharest 020956 Romania;

Vasile Goldis Western Univ Arad Dept Pharmaceut Sci Fac Pharm 86 L Rebreanu Str Arad 300041 Romania;

Vasile Goldis Western Univ Arad Dept Pharmaceut Sci Fac Pharm 86 L Rebreanu Str Arad 300041 Romania;

Univ Oradea Fac Med &

Pharm Special Pharm 29 Nicolae Jiga Str Oradea 410028 Romania;

Carol Davila Univ Med &

Pharm Fac Pharm 6 Traian Vuia Str Bucharest 020956 Romania;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
valsartan; active substance; pharmaceutical product; TG/DTG/DSC; FT-IR; X-ray;

机译：Valsartan;活性物质;药物产品;Tg / dtg / dsc;ft-Ir;X射线;

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1. Thermal Behavoiur of Valsartan Active Substance and in Pharmaceutical Products [J] . Tita Ioana Cristina, Tita Bogdan, Toma Claudia Crina, Revista de Chimie . 2017,第10期

机译：Valsartan活性物质和药物产品的热行为
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Thermal Behavoiur of Valsartan Active Substance and in Pharmaceutical Products

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