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首页> 外文期刊>Russian journal of genetics >Genetic Diversity Pattern of the MHC-LEI0258 Locus across Asian Populations of Chickens
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Genetic Diversity Pattern of the MHC-LEI0258 Locus across Asian Populations of Chickens

机译：跨亚洲鸡群的MHC-Lei0258基因座的遗传多样性模式

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摘要

The major histocompatibility complex (MHC) is surprisingly well associated with epidemiological and pathogenic environments, and the MHC-related microsatellite LEI0258 is a useful biomarker for indicating MHC haplotypes. In the present study, we conducted a comprehensive analysis of LEI0258 diversity in 492 Asian chickens and White Leghorns using multiple strategies to gain insight into the effectiveness of this adaptive locus for assessing the diversity and genetics of populations and the potential forces that affect MHC evolution. Comparisons between five Asian local breeds with wide geographic distributions and one commercial breed (White Leghorn chickens) revealed a total of 82 different alleles. The overall observed heterozygosity was 85.55% in Asian chickens and 30.98% in White Leghorn chickens, indicating higher LEI0258 diversity in Asian chickens than in the commercial breed. In addition, a population structure analysis of nine wild jungle fowl populations and several geographically varied Asian chicken populations revealed consistent clustering. Moreover, the results of AMOVA among jungle fowl populations suggested that most of the diversity was found among individuals within populations and within individuals. High levels of polymorphism and divergence were observed in the MHC region within and among populations, whereas limited polymorphisms and divergence were present among geographic groups. Hence, we concluded that the MHC in chickens has low intraspecific and interbreed variation and cannot be adapted as a tool to estimate diversity and migration based on drift and neutral events.
机译：主要的组织相容性络合物（MHC）令人惊讶地与流行病学和致病环境相关，MHC相关的微卫星LEI0258是用于指示MHC单倍型的有用生物标志物。在本研究中，我们在492个亚洲鸡和白色leghorns中综合分析了使用多种策略，深入了解这种自适应基因座的有效性，以评估种群的多样性和遗传和影响MHC演化的潜在力量。五个亚洲当地品种具有广泛地理分布和一个商业品种（White Leghorn Chickens）的比较揭示了82个不同的等位基因。亚洲鸡的整体杂合子为85.55％，白色李干鸡中30.98％，表明亚洲鸡的雷艾258多样性高于商业品种。此外，九野丛林种群的人口结构分析和几个地理上不同的亚洲鸡群揭示了一致的聚类。此外，丛林禽群中Amova的结果表明，人群内部的个人和个人内部的大多数多样性都存在。在群体内部和群体中的MHC区观察到高水平的多态性和分歧，而在地理基团中存在有限的多态性和分歧。因此，我们得出结论，鸡中的MHC具有低的内际和杂交变异，不能适应基于漂移和中性事件来估计多样性和迁移的工具。

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