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首页> 外文期刊>Occupational and environmental medicine >Early detection of lung cancer in a population at high risk due to occupation and smoking
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Early detection of lung cancer in a population at high risk due to occupation and smoking

机译：由于占领和吸烟，在高风险中的肺癌早期检测肺癌

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The US National Comprehensive Cancer Network (NCCN) recommends two pathways for eligibility for Early Lung Cancer Detection (ELCD) programmes. Option 2 includes individuals with occupational exposures to lung carcinogens, in combination with a lesser requirement on smoking. Our objective was to determine if this algorithm resulted in a similar prevalence of lung cancer as has been found using smoking risk alone, and if so to present an approach for lung cancer screening in high-risk worker populations.We enrolled 1260 former workers meeting NCCN criteria, with modifications to account for occupational exposures in an ELCD programme.At baseline, 1.6% had a lung cancer diagnosed, a rate similar to the National Lung Cancer Screening Trial (NLST). Among NLST participants, 59% were current smokers at the time of baseline scan or had quit smoking fewer than 15 years prior to baseline; all had a minimum of 30 pack-years of smoking. Among our population, only 24.5% were current smokers and 40.1% of our participants had smoked fewer than 30 pack-years; only 43.5% would meet entry criteria for the NLST. The most likely explanation for the high prevalence of screen-detected lung cancers in the face of a reduced risk from smoking is the addition of occupational risk factors for lung cancer.Occupational exposures to lung carcinogens should be incorporated into criteria used for ELCD programmes, using the algorithm developed by NCCN or with an individualised risk assessment; current risk assessment tools can be modified to incorporate occupational risk.
机译：美国国家综合癌症网络（NCCN）推荐了两种途径，可用于早期肺癌检测（ELCD）计划的资格。选项2包括具有肺癌的职业暴露的个体，同时与吸烟的要求较小。我们的目的是确定该算法是否导致肺癌的普遍存在，因为已经发现吸烟风险，如果出现在高风险工人群体中肺癌筛查的方法。我们注册了1260名前工人遇见NCCN标准，具有修改，以考虑ELCD计划中的职业暴露.AT基线，1.6％患有肺癌诊断的肺癌，一种与国家肺癌筛查试验（NLST）相似的速率。在NLST参与者中，59％是当前吸烟者在基线扫描时或在基线前少于15年吸烟;所有人都至少有30包的吸烟。在我们的人口中，只有24.5％的吸烟者，40.1％的参与者吸烟了少于30包;只有43.5％会符合NLST的入门标准。面对吸烟风险降低的筛选肺癌高患病率最有可能的解释是增加肺癌的职业危险因素。肺癌的妇女曝光应纳入用于ELCD程序的标准，使用NCCN开发的算法或具有个性化风险评估;可以修改当前风险评估工具以纳入职业风险。

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