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首页> 外文期刊>Occupational and environmental medicine >Night shift work and abnormal liver function: is non-alcohol fatty liver a necessary mediator?
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Night shift work and abnormal liver function: is non-alcohol fatty liver a necessary mediator?

机译：夜班工作和异常肝功能：是非酒精脂肪肝的必要介质吗？

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摘要

Accumulated evidence implies that night shift work may trigger liver dysfunction. Non-alcoholic fatty liver (NAFL) is suggested to be a necessary mediator in this process. This study aimed to examine the relationship between night shift work and elevated level of alanine transaminase (e-ALT) of workers and investigate the potential mediation effect of NAFL.This study included all male workers from the baseline survey of a cohort of night shift workers. Information on demographics, lifestyle and lifetime working schedule was collected by face-to-face interview. Liver sonography was used to identify NAFL cases. Serum ALT level was detected by an automatic biochemical analyser. e-ALT was defined as ALT >40?U/L. Logistic regression models were used to evaluate ORs, and mediation analysis was employed to examine the mediation effect.Among 4740 male workers, 39.5% were night shift workers. Night shift workers had an increased risk of e-ALT (OR, 1.19, 95%?CI 1.00 to 1.42). With the increase in night shift years, the OR of e-ALT increased from 1.03 (95% CI 0.77 to 1.36) to 1.60 (95% CI 1.08 to 2.39) among workers without NAFL. A similar trend was not found among workers with NAFL. In addition, no significant mediation effect of NAFL in the association between night shift work and e-ALT was found.Night shift work is positively associated with abnormal liver function, in particular among workers without NAFL. Shift work involving circadian disruption is likely to exert a direct effect on liver dysfunction rather than rely on the mediation effect of NAFL.
机译：累积的证据意味着夜班工作可能会引发肝功能障碍。在该过程中，建议是非酒精性脂肪肝（NAFL）是必要的介体。本研究旨在研究夜班工作与工人丙氨酸转氨酶（E-ALT）升高水平的关系，并调查NAFL的潜在调解效应。本研究包括来自夜班队伍队列的基线调查的所有男性工人。面对面采访收集有关人口统计学，生活方式和终身工作时间表的信息。肝超声检查用于鉴定NAFL病例。自动化生物化学分析仪检测血清ALT水平。 E-Alt被定义为ALT> 40？U / L.逻辑回归模型用于评估或者，采用调解分析来检查调解效果.AMONG 4740男性工人，39.5％是夜班工人。夜班工人的e-alt风险增加（或1.19,95％？ci 1.00至1.42）。随着夜班岁月的增加，E-Alt的或E-Alt从1.03（95％CI 0.77至1.36）增加到1.60（95％CI 1.08至2.39），而没有NAFL。 NAFL的工人之间没有找到类似的趋势。此外，发现NAFL在夜班工作和E-ALT之间的关联中没有显着的介调作用。夜间换档工作与肝功能异常相关，特别是在没有NAFL的工人中。涉及昼夜振荡的转变工作可能对肝功能障碍产生直接影响，而不是依赖于NAFL的调解效果。

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    Feng Wang; Liuzhuo Zhang; Suyang Wu; Wentao Li; Miaomiao Sun; Wenting Feng; Ding Ding; Samuel Yeung-shan Wong; Peng Zhu; Greg J Evans; Yun Kwok Wing; Jihui Zhang; Jelle J Vlaanderen; Roel C H Vermeulen; Yanfang Zhang; Emily Ying-yang Chan; Zhimin Li; Lap Ah Tse;

  • 作者单位

    JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong China;

    Institute of Occupational Medicine Shenzhen Prevention and Treatment Center for Occupational;

    JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong China;

    JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong China;

    JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong China;

    Institute of Occupational Medicine Shenzhen Prevention and Treatment Center for Occupational;

    Institute of Neurology National Clinical Research Center for Aging Diseases Huashan Hospital;

    JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong China;

    Hepatic Surgery Center Tongji Hospital Tongji Medical College Huazhong University of Science and;

    Occupational and Environmental Health Division Dalla Lana School of Public Health University of;

    Department of Psychiatry The Chinese University of Hong Kong Hong Kong China;

    Department of Psychiatry The Chinese University of Hong Kong Hong Kong China;

    Environmental Epidemiology Institute for Risk Assessment Sciences (IRAS) Utrecht University;

    Environmental Epidemiology Institute for Risk Assessment Sciences (IRAS) Utrecht University;

    Institute of Occupational Medicine Shenzhen Prevention and Treatment Center for Occupational;

    JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong China;

    Institute of Occupational Medicine Shenzhen Prevention and Treatment Center for Occupational;

    JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 劳动卫生;
  • 关键词

    shift work; liver function; mediation effect; non-alcoholic fatty liver;

    机译：转移工作;肝功能;调解效果;非酒精脂肪肝;

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