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首页> 外文期刊>Reproductive toxicology >Elevated blood mercury level has a non-linear association with infertility in US women: Data from the NHANES 2013-2016
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Elevated blood mercury level has a non-linear association with infertility in US women: Data from the NHANES 2013-2016

机译：血液汞水平升高与美国女性不孕症的非线性关联：来自Nhanes 2013-2016的数据

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摘要

Mercury is a ubiquitous toxic heavy metal associated with an increased risk of female infertility; however, the evidence supporting this is limited and controversial. We aimed to explore the relationship between the total blood mercury and infertility in 1796 selected participants from the National Health and Nutrition Examination Survey (NHANES) (2013-2016). We found no significant association between mercury and infertility based on a fully-adjusted model (OR 1.04; 95 % CI 0.91, 1.19), and the results remained robust in a series of sensitive analysis. However, a non-linear relationship was detected. By a two-piecewise linear regression model and recursive algorithm, we identified an inflection point of 5.278 mu g/L, when blood mercury was > 5.278 mu g/L, a 1-unit increase in mercury (log2) was associated with 157 % greater adjusted odds of infertility (OR 2.57; 95 % CI 1.12, 5.87). Our findings provide new insights to advance the research of the link between mercury and infertility.
机译：汞是一种与患有女性不孕症的风险增加相关的无处不在的毒性重金属; 但是，支持这一点的证据是有限的和争议的。 我们的目标是探讨来自国家卫生和营养考试调查（NHANES）的1796名选定参与者的血液汞和不育症之间的关系（2013-2016）。 我们发现基于完全调整的模型（或1.04; 95％CI 0.91,119）之间的汞和不孕症之间没有显着关联，并且结果在一系列敏感分析中保持稳健。 但是，检测到非线性关系。 通过双分段的线性回归模型和递归算法，我们确定了5.278 mu g / l的拐点，当血液汞>5.278μmg/ l时，汞（log2）的1单位增加与157％有关 更高的不孕症的调整差异（或2.57; 95％CI 1.12,5.87）。 我们的调查结果提供了新的见解，以推进汞和不孕症之间联系的研究。

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