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首页> 外文期刊>Reproductive toxicology >Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils
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Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils

机译：双酚-S促进与成人Gerbils前列腺促进的促进的内分泌破坏效果

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This study evaluated the effects of BPS (40 mu g/kg/day, during 28 consecutive days) on the male ventral prostate and female prostate of adult gerbils. For comparative purposes, gerbils were also exposed to BPA under the same experimental conditions. The prostates were submitted to biometric, morphometric, histopathological, immunohistochemical and ultrastructural analyses. The results demonstrated that exposure to both types of bisphenol caused no changes in testosterone or estradiol serum levels. Morphologically, the effects of BPS and BPA on female prostates were similar and included changes in prostatic tissue compartments, glandular hyperplasia, AR and ER alpha up-regulation and increased cell proliferation. In males, BPS and BPA promoted differential effects, since the prostate presented morphological changes and proliferative disorders that were more pronounced in the BPS group. Therefore, this study demonstrates that BPS caused endocrine disruption in the prostate of male and female gerbils.
机译：该研究评估了BPS（40μg/ kg /天，连续28天）对成年人患者的雄性前列腺和女性前列腺作用。出于比较目的，在相同的实验条件下，Gerbils也暴露于BPA。前列腺提交至生物统计学，形态术，组织病理学，免疫组化和超微结构分析。结果表明，暴露于两种类型的双酚导致睾酮或雌二醇血清水平的变化。形态学上，BPS和BPA对女性前列腺的影响是相似的，包括前列腺组织隔室，腺体增生，AR和ERα上调的变化和细胞增殖。在雄性，BPS和BPA促进差异效应，因为前列腺呈现在BPS组中更明显的形态变化和增殖性疾病。因此，本研究表明，BPS导致男性和女性沙鼠前列腺中的内分泌破坏。

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