Effect of Chlorpyrifos on human extravillous-like trophoblast cells

Ridano Magali E.; Racca Ana C.; Flores-Martin Jesica B.; Reyna Luciana; Genti-Raimondi Susana; Panzetta-Dutari Graciela M.

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Effect of Chlorpyrifos on human extravillous-like trophoblast cells

机译：紫紫外欲对人外向性滋养细胞的影响

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An increased risk of pregnancy disorders has been reported in women and animal models exposed to organophosphate pesticides. However, less information is available on impacts to human placental function. Here, we addressed the impact of chlorpyrifos (CPF) on extravillous cytotrophoblasts (evCTB) employing HTR8/SVneo cells as an in vitro model. Cell proliferation, migration and invasion were not affected by CPF under conditions where cell viability was not compromised; however, we observed reduced expression of genes for vascular endothelial growth factor receptor 1, hypoxia-inducible factor 1-alpha, peroxisome proliferator activated receptor gamma, and the beta-subunit of human chorionic gonadotropin. These results are the first effects reported by organophosphate pesticide in evCTB cells and show altered expression of several genes important for placental development that could serve as potential biomarkers for future research.

机译：在暴露于有机磷酸盐农药的妇女和动物模型中据报道妊娠障碍的风险增加。但是，对人类胎盘功能的影响较少。在这里，我们解决了氯吡啶（CPF）对使用HTR8 / Svneo细胞作为体外模型的含外培素细胞培育物（EVCTB）的影响。细胞增殖，迁移和侵袭在细胞活力未受到损害的条件下不受CPF的影响; 然而，我们观察到对血管内皮生长因子受体1，缺氧诱导因子1-α，过氧化物体增殖剂活化受体γ的缺氧诱导因子1-α，活性组和人绒毛膜促性腺激素的β-亚基的表达减少。这些结果是EVCTB细胞中有机磷农药报告的第一次效果，并显示出对胎盘发展重要的几种基因的表达改变，这可能是未来研究的潜在生物标志物。

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来源
《Reproductive toxicology》 |2019年第2019期|共8页
作者
Ridano Magali E.; Racca Ana C.; Flores-Martin Jesica B.; Reyna Luciana; Genti-Raimondi Susana; Panzetta-Dutari Graciela M.;
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作者单位

Univ Nacl Cordoba Fac Ciencias Quim Dept Bioquim Clin Ciudad Univ X5000HUA Cordoba Argentina;

Univ Nacl Cordoba Fac Ciencias Quim Dept Bioquim Clin Ciudad Univ X5000HUA Cordoba Argentina;

Univ Nacl Cordoba Fac Ciencias Quim Dept Bioquim Clin Ciudad Univ X5000HUA Cordoba Argentina;

Univ Nacl Cordoba Fac Ciencias Quim Dept Bioquim Clin Ciudad Univ X5000HUA Cordoba Argentina;

Univ Nacl Cordoba Fac Ciencias Quim Dept Bioquim Clin Ciudad Univ X5000HUA Cordoba Argentina;

Univ Nacl Cordoba Fac Ciencias Quim Dept Bioquim Clin Ciudad Univ X5000HUA Cordoba Argentina;

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正文语种 eng
中图分类毒物学（毒理学）;
关键词
Organophosphate pesticide; Placental cells; Proliferation; Migration; Gene expression;

机译：有机磷杀虫剂;胎盘细胞;增殖;迁移;基因表达;

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1. Effect of Chlorpyrifos on human extravillous-like trophoblast cells [J] . Ridano Magali E., Racca Ana C., Flores-Martin Jesica B., Reproductive toxicology . 2019,第期

机译：紫紫外欲对人外向性滋养细胞的影响
2. Impact of chlorpyrifos on human villous trophoblasts and chorionic villi [J] . M.E. Ridano, A.C. Racca, J.B. Flores-Martin, Toxicology and Applied Pharmacology . 2017,第期

机译：紫紫外欲对人类绒式滋养细胞和绒毛膜绒毛的影响
3. CHLORPYRIFOS EXPOSURE INDUCES TROPHOBLAST BARRIER AND STROMA ALTERATIONS IN HUMAN CHORIONIC VILLOUS EXPLANTS [J] . Ridano M. E., Racca A. C., Flores-Martin J. B., Placenta . 2015,第4期

机译：氯氟酸暴露可导致人绒毛膜绒毛膜滋养层屏障和间质改变。
4. Leukemia Inhibitory Factor (LIF) and Vascular Endothelial Growth Factor (VEGF) diminish intensity of apoptosis in hypoxic human trophoblast: first- trimester versus term trophoblast cultures. [C] . DARIUSZ SZUKIEWICZ, MICHAL PYZLAK, ALEKSANDRA STANGRET, Recent advances in clinical medicine . 2010

机译：白血病抑制因子（LIF）和血管内皮生长因子（VEGF）降低了缺氧人滋养细胞的凋亡强度：早孕期与足月滋养层培养相比。
5. Identification of oxygen optima for mouse trophoblast stem cells and human embryos and the stress responses upon departing optima. [D] . Yang, Yu. 2017

机译：鉴定小鼠滋养层干细胞和人类胚胎的最佳氧含量，以及离开最佳值时的应激反应。
6. Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells [O] . C. Rossmann, A. Hammer, C.N. Koyani, -1

机译：血清淀粉样蛋白A4在人滋养细胞样绒毛膜癌细胞和人早孕/足月滋养细胞中的表达
7. Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells [O] . Rossmann C., Hammer A., Koyani C.N., 2014

机译：血清淀粉样蛋白A4在人滋养细胞样绒毛膜癌细胞和人早孕/足月滋养细胞中的表达

Effect of Chlorpyrifos on human extravillous-like trophoblast cells

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