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首页> 外文期刊>Reproductive toxicology >Effects of hydroxychloroquine on the human placenta-Findings from in vitro experimental data and a systematic review
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Effects of hydroxychloroquine on the human placenta-Findings from in vitro experimental data and a systematic review

机译：羟基氯喹对体外实验数据的人胎盘调查结果和系统评价的影响

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Hydroxychloroquine (HCQ), a toll like receptor (TLR) 7 and 9 antagonist, is used during pregnancy for inflammatory conditions with limited understanding of its placental toxicology. We hypothesized that HCQ does not have toxic effects on the placenta and can modulate cytokine release in response to TLR7/9 activation. A systematic review was conducted and no studies of HCQ on multicellular human placental tissue were identified. Accordingly, placental villous explants were cultured for 7 days with HCQ +/- TLR7/9 agonists. HCQ did not affect cell turnover, nutrient transport or cytokine release but increased IL-10 (anti-inflammatory) secretion and promoted syncytiotrophoblast regeneration. Cytokine release stimulated by TLR7/9 agonists was unaffected by HCQ. In conclusion, HCQ did not adversely affect placental tissue and may have a protective anti-inflammatory function. Further research is needed to determine the mechanisms of HCQ actions on human placenta and whether they could be utilized to improve pregnancy outcomes.
机译：羟基氯喹（HCQ），一种损伤等受体（TLR）7和9拮抗剂在妊娠期间用于炎症条件，了解其胎盘毒理学有限。我们假设HCQ对胎盘没有毒性作用，并且可以响应于TLR7 / 9激活调节细胞因子释放。对系统审查进行了系统评价，确定了HCQ对多细胞人胎盘组织的研究。因此，用HCQ +/-TLR7 / 9激动剂培养胎盘绒毛植物7天。 HCQ不影响细胞周转，营养转运或细胞因子释放，而是增加IL-10（抗炎）分泌和促进的单胞生殖细胞再生。 TLR7 / 9激动剂刺激的细胞因子释放不受HCQ的影响。总之，HCQ不会对胎盘组织产生不利影响，并且可能具有保护性抗炎功能。需要进一步的研究来确定人类胎盘的HCQ行动的机制，以及它们是否可用于改善妊娠结果。

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