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Evaluation of a new tricalcium phosphate for guided bone regeneration: an experimental study in the beagle dog

机译：评估引导骨再生的新磷酸钙：小猎犬犬实验研究

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摘要

This study compared the in vivo behavior of two biomaterials, xenograft (Bio-Oss((R))) and alloplastic tricalcium phosphate (Sil-Oss((R))), vs a control (no biomaterial) in beagle dogs treated with guided bone regeneration (GBR). Six male adult beagle dogs were included. The third and fourth mandibular premolars and first mandibular molars (3P3, 4P4 and 1M1) on both sides were extracted. After 12weeks of healing, Straumann implants (3.3x8mm) were placed, performing standardized defects (3.3x6mm) in the vestibular aspect of the alveolar bone. The defects were surgically treated by randomized placement of xenograft (Bio-Oss((R))), alloplastic tricalcium phosphate (Sil-Oss((R))) or no biomaterial and covered with a resorbable collagen membrane (BioGide((R))). After an additional 12-week healing period, the lower jaws were dissected. Total area regenerated in the region of interest, total volume, bone to implant contact in the regenerated area, and volumetric changes were measured through histological, histomorphometrical and microcomputed tomography (microCT) techniques. The negative control group showed bone ingrowth inside the defect, with a partial collapse of the buccal bone. This was not observed in the biomaterial-treated groups. Defects treated with the xenograft showed 51.40% (SD 19.83) newly mineralized tissue, while those treated with alloplastic tricalcium showed 62.54% (SD 11.54) newly mineralized tissue; the control showed 71.52% (SD 6.46). Alloplastic tricalcium phosphate modified with monetite and zinc showed similar features in alveolar regeneration of defects to those treated with the xenograft or conventional GBR, but it showed an ideally higher rate of new mineralized tissue formation and accelerated resorption.
机译：该研究比较了两种生物材料的体内行为，异种移植物（Bio-OSS（（r）））和分子塑性磷酸钙（Sil-OSS（（r））），在被引导的比赛犬的对照（没有生物材料）骨再生（GBR）。包括六只男性成人格子狗。提取两侧的第三和第四个下颌前磨牙和第一下颌臼齿（3P3，4P4和1M1）。在愈合12周后，将施特鲁曼植入物（3.3x8mm）放置，在肺泡骨前庭方面进行标准化缺陷（3.3x6mm）。通过异种移植物的随机放置（Bio-OSS（（R））），磷酸盐（Sil-OSS）（（r）））或未覆盖可再吸收的胶原膜（Feogide（Biogide（（r）（（r） ）））。在额外的12周愈合期后，解剖下颚。通过组织学，组织学和微型断层扫描（MicroCT）技术测量在感兴趣区域中再生的总体积，总体积，骨骼植入接触和体积变化。阴性对照组在缺陷内显示出骨骼的骨骼，颊骨的部分塌陷。在生物材料治疗组中未观察到这一点。用异种移植物处理的缺陷显示出51.40％（SD 19.83）新的矿化组织，而用双塑性三钙处理的那些均显示出62.54％（SD 11.54）新矿化组织;该对照显示71.52％（SD 6.46）。用碳酸盐和锌改性的所有磷酸盐磷酸盐在肺泡或常规GBR处理的缺陷的肺泡再生中显示出类似的特征，但它显示出较高的新型矿化组织形成和加速的吸收率。

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