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首页> 外文期刊>Odontology >Calcium sustained release, pH changes and cell viability induced by chitosan-based pastes for apexification
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Calcium sustained release, pH changes and cell viability induced by chitosan-based pastes for apexification

机译：Chitosan基浆料诱导的钙持续释放，pH变化和细胞活力进行辐射

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We explored chitosan-based sustained release pastes for apexification. The study aimed to formulate chitosan-based pastes loaded with calcium hydroxide (CH) or with calcium chloride (CC), and to evaluate the sustained release of Ca2+ and pH changes in deionized water as well as the effect of the pastes on cell viability. The pastes were formulated by dissolution of the chitosan in 1% or 2% acetic acid (AAC) plus the addition of CH or CC, then were suspended in deionized water for 50 days; the released Ca(II) and pH were measured with an electrode probe. The effect of the pastes on viability of human dental pulp cells was evaluated with a MTS assay. The results showed that the pastes prepared with 1% and 2% AAC and loaded with CH released a 74.9% and a 76.1% of the Ca2+ content, respectively, while the pastes prepared with 1% and 2% AAC loaded with CC released a content of Ca2+ of 90.8% and 76.6%, respectively. A control paste (CH and polyethylene glycol) released a 95.4%; significant statistical differences were found between the percentage of the experimental pastes and the control. The CH-loaded pastes caused an alkaline pH at the starting of the study, but the pH became neutral at the ending. The pH of the CC-loaded pastes was neutral at the starting and was acid at the ending. The pastes no affected on the cell viability. The chitosan-based pastes showed a suitable sustained release profile and cytocompatibility.
机译：我们探索了基于壳聚糖的持续释放浆料进行了曝光。该研究旨在配制用氢氧化钙（CH）或用氯化钙（CC）装配壳聚糖的糊状物，并评估Ca2 +和去离子水中的pH变化的持续释放以及浆料对细胞活力的影响。通过壳聚糖溶解在1％或2％乙酸（AAC）中加上CH或Cc的加入CH或Cc，将糊状物配制，然后将去离子水中悬浮50天;用电极探针测量释放的Ca（II）和pH。用MTS测定评估浆料对人牙髓细胞活力的影响。结果表明，用1％和2％AAC制备的糊状物分别释放出74.9％和76.1％的CA2 +含量，同时用1％和2％AAC制备的糊状物释放含量Ca2 +分别为90.8％和76.6％。对照糊（CH和聚乙二醇）释放出95.4％;在实验浆料的百分比和对照之间发现了显着的统计差异。 Ch装载的糊状物在研究开始时引起碱性pH值，但在结束时，pH值变得中性。 CC负载糊剂的pH在起始时是中性的，并且在结束时是酸。糊状物没有受到细胞活力的影响。基于壳聚糖的糊状物显示出合适的持续释放曲线和细胞粘合性。

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