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首页> 外文期刊>Oncology letters >Hispolon as an inhibitor of TGF-beta-induced epithelial-mesenchymal transition in human epithelial cancer cells by co-regulation of TGF-beta-Snail/Twist axis
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Hispolon as an inhibitor of TGF-beta-induced epithelial-mesenchymal transition in human epithelial cancer cells by co-regulation of TGF-beta-Snail/Twist axis

机译：Hisogolon作为TGF-Beta-蜗牛/扭曲轴的共调节，作为人上皮癌细胞中TGF-Beta诱导的TGF-Beta诱导的上皮 - 间充质转变的抑制剂

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摘要

Hispolon (HPL), isolated from Phellinus linteus, has been used to treat various types of pathology, including inflammation, gastroenteric disorders, lymphatic diseases and numerous cancer subtypes. HPL has previously been reported to demonstrate a significant therapeutic efficacy against various types of cancer cells, including melanoma, leukemia, hepatocarcinoma, bladder and gastric cancer cells. However, its potential role in the epithelial-mesenchymal transition (EMT) has not been demonstrated. The present study investigated the effects of HPL on the EMT. Transforming growth factor beta (TGF-beta) induced enhanced cell migration and invasion, EMT-associated phenotypic changes. In the present study, HPL recovered the reduction of E-cadherin expression level in TGF-beta treated cancer cells, which was regulated by the expression of Snail and Twist. HPL downregulated Snail and Twist, an effect that was enhanced by TGF-beta. These findings provide novel evidence that HPL suppresses cancer cell migration and invasion by inhibiting EMT. Therefore, HPL may be a potent anticancer agent, inhibiting metastasis.
机译：Hispolon（HPL）与Phellinus Linteus隔离，已被用于治疗各种类型的病理学，包括炎症，胃肠疾病，淋巴病和许多癌症亚型。先前据报道，HPL旨在证明对各种类型的癌细胞的显着治疗疗效，包括黑素瘤，白血病，肝癌，膀胱和胃癌细胞。然而，其在上皮 - 间充质转换（EMT）中的潜在作用尚未得到证实。本研究研究了HPL对EMT的影响。转化生长因子β（TGF-Beta）诱导增强细胞迁移和侵袭，EMT相关的表型变化。在本研究中，HPL在TGF-β处理的癌细胞中回收了E-Cadherin表达水平的降低，其通过表达蜗牛和扭曲来调节。 HPL下调蜗牛和扭曲，TGF-β增强的效果。这些发现提供了新的证据，即HPL通过抑制EMT来抑制癌细胞迁移和侵袭。因此，HPL可以是抑制转移的有效抗癌剂。

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