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首页> 外文期刊>Oncology letters >Disappearance of bone metastases in chemotherapy-resistant gastric cancer treated with antigen peptide-pulsed dendritic cell-activated cytotoxic T lymphocyte immunotherapy: A case report
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Disappearance of bone metastases in chemotherapy-resistant gastric cancer treated with antigen peptide-pulsed dendritic cell-activated cytotoxic T lymphocyte immunotherapy: A case report

机译：用抗原肽脉冲树突细胞 - 活化细胞毒性T淋巴细胞免疫治疗抗化疗抗性胃癌中骨转移的消失：案例报告

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摘要

The adoptive transfer of cytotoxic T lymphocytes (CTLs) stimulated by specific tumor antigen peptide-pulsed dendritic cells (DCs) is one of the most promising immunotherapeutic strategies currently available for patients with gastric cancer (GC). The present case report describes a patient with chemotherapy-resistant stage IV GC with multiple bone metastases, who had been treated with antigen peptide-pulsed DC-CTLs. DCs and CTLs were transfused into the patient subcutaneously and intravenously with simultaneous oral administration of low-dose cyclophosphamide. Following 3 cycles of combination therapy, marked remission regarding the number of metastatic bone lesions was achieved, confirmed by the use of enhanced computerized tomography, computerized tomography and magnetic resonance imaging. After 1 year, 8 cycles of adoptive immunotherapy were administered, and a further decrease in the number of metastatic bone lesions was observed in addition to a marked improvement in the patient's quality of life. Therefore, personalized antigen peptide-pulsed DC-CTLs combined with oral administration of low-dose cyclophosphamide may serve as a promising anticancer therapy to eradicate tumor cells, and therefore this approach is recommended for future cases of a similar nature.
机译：由特异性肿瘤抗原肽 - 脉冲树突状细胞（DCS）刺激的细胞毒性T淋巴细胞（CTL）的通过是目前可用于胃癌（GC）患者目前最有前途的免疫治疗策略之一。本病例报告描述了具有多种骨转移的化疗抗性阶段IV GC的患者，其被抗原肽脉冲DC-CTL处理。通过同时口服低剂量环磷酰胺，皮下和静脉内将DCS和CTL转入患者中。在3个联合治疗循环后，通过使用增强的计算机层析造影，计算机断层扫描和磁共振成像确认，实现了关于转移性骨病变的数量的标记缓解。 1年后，施用8个循环的过缔疗法，除了患者生活质量的显着改善之外，还观察到转移性骨病变的数量进一步降低。因此，个性化抗原肽脉冲DC-CTL与低剂量环磷酰胺的口服施用可以用作消除肿瘤细胞的有前途的抗癌疗法，因此建议这种方法用于未来类似性的情况。

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