...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Oncology Research >Long Noncoding RNA CCAL Promotes Papillary Thyroid Cancer Progression by Activation of NOTCH1 Pathway
【24h】

Long Noncoding RNA CCAL Promotes Papillary Thyroid Cancer Progression by Activation of NOTCH1 Pathway

机译：长的非致rna ccal通过活化促进Notch1途径促进乳头状甲状腺癌进展

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Long noncoding RNA CCAL has been reported to promote tumor progression in various human cancers, including hepatocellular carcinoma, osteosarcoma, and colorectal cancer. However, the role of CCAL in papillary thyroid cancer remains largely unknown. In the present study, we found that the expression of CCAL was upregulated in papillary thyroid tumor tissues compared to adjacent normal tissues. Moreover, the expression of CCAL was positively related with papillary thyroid cancer severity and TNM stage and predicated poor prognosis. Besides, we found that knockdown of CCAL significantly inhibited papillary thyroid cancer cell proliferation, migration, and invasion in vitro and reduced tumor growth and metastasis in vivo. We found that knockdown of CCAL dramatically decreased the expression of NOTCH1 and suppressed the activation of the NOTCH1 signaling pathway. Furthermore, overexpression of NOTCH1 rescued the proliferation, migration, and invasion in papillary thyroid cancer cells. Taken together, our data indicated that CCAL promoted papillary thyroid cancer development and progression by activation of the NOTCH1 pathway, which provided a new insight on the design of therapeutic targets.
机译：据报道，长期非编码RNA CCAL促进各种人类癌症中的肿瘤进展，包括肝细胞癌，骨肉瘤和结肠直肠癌。然而，CCAL在乳头状甲状腺癌中的作用仍然很大程度上是未知的。在本研究中，与相邻的正常组织相比，我们发现在乳头状甲状腺肿瘤组织中升高了CCAL的表达。此外，CCAL的表达与乳头状甲状腺癌严重程度和TNM阶段的表达呈正相关，并预测预后差。此外，我们发现CCAL的敲低显着抑制了乳头状甲状腺癌细胞增殖，迁移和侵袭体外肿瘤生长和转移。我们发现CCAL的敲低显着降低了Notch1的表达并抑制了Notch1信号通路的激活。此外，Notch1的过度表达抢救了乳头状甲状腺癌细胞中的增殖，迁移和侵袭。我们的数据表明，CCAL通过激活Notch1途径促进了乳头状甲状腺癌的开发和进展，这为治疗目标设计提供了新的洞察力。

著录项

  • 来源
    《Oncology Research》 |2018年第9期|共8页
  • 作者

    Ye Ying; Song Yanan; Zhuang Juhua; He Saifei; Ni Jing; Xia Wei;

  • 作者单位

    Shanghai Univ Tradit Chinese Med Peoples Hosp 7 Dept Nucl Med 1200 Cai Lun Rd Shanghai 201203;

    Shanghai Univ Tradit Chinese Med Peoples Hosp 7 Dept Nucl Med 1200 Cai Lun Rd Shanghai 201203;

    Shanghai Univ Tradit Chinese Med Peoples Hosp 7 Dept Nucl Med 1200 Cai Lun Rd Shanghai 201203;

    Shanghai Univ Tradit Chinese Med Peoples Hosp 7 Dept Nucl Med 1200 Cai Lun Rd Shanghai 201203;

    Shanghai Univ Tradit Chinese Med Peoples Hosp 7 Dept Nucl Med 1200 Cai Lun Rd Shanghai 201203;

    Shanghai Univ Tradit Chinese Med Peoples Hosp 7 Dept Nucl Med 1200 Cai Lun Rd Shanghai 201203;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

    Papillary thyroid cancer; Colorectal cancer-associated lncRNA (CCAL); Proliferation; Migration; NOTCH1;

    机译：乳头状甲状腺癌;结肠直肠癌相关的LNCRNA（CCAL）;增殖;迁移;NOTCH1;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号