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首页> 外文期刊>Oncology Research >Knockdown of Ras-Related Protein 25 (Rab25) Inhibits the In Vitro Cytotoxicity and In Vivo Antitumor Activity of Human Glioblastoma Multiforme Cells
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Knockdown of Ras-Related Protein 25 (Rab25) Inhibits the In Vitro Cytotoxicity and In Vivo Antitumor Activity of Human Glioblastoma Multiforme Cells

机译：RAS相关蛋白25（RAB25）的敲低抑制了体外细胞毒性和人胶质母细胞的体内抗肿瘤活性

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摘要

Ras-related protein 25 (Rab25) is a member of the Rab family, and it has been reported to play an important role in tumorigenesis. However, its direct involvement in human glioblastoma multiforme (GBM) is still unclear. The aim of the current study was to investigate the potential role of Rab25 in the growth, proliferation, invasion, and migration of human GBM. Our results showed that Rab25 expression was significantly higher in human GBM cell lines compared with a normal astrocyte cell line. In vitro functional studies revealed that knockdown of Rab25 reduced cell proliferation and inhibited invasion and migration of GBM cells. In vivo experiments showed that knockdown of Rab25 attenuated the tumor growth in nude mice. Finally, knockdown of Rab25 significantly inhibited the phosphorylation levels of PI3K and AKT in GBM cells. Taken together, these findings indicate that Rab25 may act as a tumor promoter in human GBM and that approaches to target Rab25 may provide a novel strategy to treat this disease.
机译：RAS相关蛋白25（RAB25）是RAB系列的成员，据报道，据报道，在肿瘤发生中发挥重要作用。然而，它直接参与人胶质母细胞瘤多形态（GBM）仍然不清楚。目前研究的目的是探讨RAB25在人GBM的生长，增殖，入侵和迁移中的潜在作用。我们的研究结果表明，与正常的星形胶质细胞系相比，人GBM细胞系中的rab25表达明显高。体外功能研究表明，RAB25的敲低降低了细胞增殖和抑制GBM细胞的侵袭和迁移。体内实验表明，RAB25的敲低衰减了裸鼠的肿瘤生长。最后，RAB25的敲低显着抑制了GBM细胞中PI3K和AKT的磷酸化水平。这些发现表明，RAB25可以充当人GBM中的肿瘤启动子，靶标rab25的方法可以提供一种治疗这种疾病的新策略。

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  • 来源
    《Oncology Research》 |2017年第3期|共10页
  • 作者

    Ding Bingqian; Cui Bei; Gao Ming; Li Zhenjiang; Xu Chenyang; Fan Shaokang; He Weiya;

  • 作者单位

    Huaihe Hosp Henan Univ Dept Neurol Baobei Rd 8 Kaifeng 475000 Peoples R China;

    Huaihe Hosp Henan Univ Dept Neurol Baobei Rd 8 Kaifeng 475000 Peoples R China;

    Huaihe Hosp Henan Univ Dept Neurol Baobei Rd 8 Kaifeng 475000 Peoples R China;

    Huaihe Hosp Henan Univ Dept Neurol Baobei Rd 8 Kaifeng 475000 Peoples R China;

    Huaihe Hosp Henan Univ Dept Neurol Baobei Rd 8 Kaifeng 475000 Peoples R China;

    Huaihe Hosp Henan Univ Dept Neurol Baobei Rd 8 Kaifeng 475000 Peoples R China;

    Huaihe Hosp Henan Univ Dept Neurol Baobei Rd 8 Kaifeng 475000 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

    Ras-related protein 25 (Rab25); Glioblastoma multiforme (GBM); Migration; Invasion;

    机译：RAS相关蛋白25（RAB25）;胶质母细胞瘤多形形（GBM）;迁移;入侵;

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