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首页> 外文期刊>Oncology Research >Knockdown of Serine-Arginine Protein Kinase 1 Inhibits the Growth and Migration in Renal Cell Carcinoma Cells
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Knockdown of Serine-Arginine Protein Kinase 1 Inhibits the Growth and Migration in Renal Cell Carcinoma Cells

机译：丝氨酸 - 精氨酸蛋白激酶1的敲低抑制肾细胞癌细胞的生长和迁移

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摘要

The pre-mRNA splicing regulator serine-arginine protein kinase 1 (SRPK1), a member of the SR kinase family, plays an essential role in cancer development and various pathophysiological processes. However, its expression pattern and functions in renal cell carcinoma (RCC) remain unknown. Therefore, the aim of this study was to assess the role of SRPK1 in RCC. Our data showed that SRPK1 was significantly upregulated in human RCC tissues and cell lines. SRPK1 interference significantly inhibited the proliferation of RCC cells and inhibited tumor growth in vivo. In addition, SRPK1 interference also suppressed migration and invasion in RCC cells. A mechanistic study showed that SRPK1 interference inhibited the phosphorylation of PI3K and Akt in RCC cells. In conclusion, our findings suggest that SRPK1 interference inhibits the growth and invasion of RCC cells through suppressing the PI3K/Akt signaling pathway. Thus, SRPK1 might be a therapeutic target for the treatment of RCC.
机译：前mRNA剪接调节剂丝氨酸 - 精氨酸蛋白激酶1（SRPK1），SR激酶家族的成员在癌症发育和各种病理生理过程中起重要作用。 然而，其在肾细胞癌（RCC）中的表达模式和功能仍然是未知的。 因此，本研究的目的是评估SRPK1在RCC中的作用。 我们的数据显示SRPK1在人RCC组织和细胞系中显着上调。 SRPK1干扰显着抑制RCC细胞的增殖并抑制体内肿瘤生长。 此外，SRPK1干扰还抑制了RCC细胞中的迁移和侵袭。 机械研究表明，SRPK1干扰抑制了PI3K和AKT在RCC细胞中的磷酸化。 总之，我们的研究结果表明SRPK1干扰通过抑制PI3K / AKT信号通路来抑制RCC细胞的生长和侵袭。 因此，SRPK1可能是治疗RCC的治疗靶标。

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  • 来源
    《Oncology Research》 |2017年第3期|共7页
  • 作者

    Han Xingtao; Yang Jinjian; Jia Zhankui; Wei Pengtao; Zhang Han; Lv Wenwei; Sun Jiantao; Huo Qingxiang;

  • 作者单位

    Zhengzhou Univ Affiliated Hosp 1 Dept Urol 1 Jianshe Rd Zhengzhou 450052 Peoples R China;

    Zhengzhou Univ Affiliated Hosp 1 Dept Urol 1 Jianshe Rd Zhengzhou 450052 Peoples R China;

    Zhengzhou Univ Affiliated Hosp 1 Dept Urol 1 Jianshe Rd Zhengzhou 450052 Peoples R China;

    Zhengzhou Univ Luoyang Cent Hosp Affiliated Dept Urol Luoyang Peoples R China;

    Zhengzhou Univ Luoyang Cent Hosp Affiliated Dept Urol Luoyang Peoples R China;

    Zhengzhou Univ Luoyang Cent Hosp Affiliated Dept Urol Luoyang Peoples R China;

    Zhengzhou Univ Luoyang Cent Hosp Affiliated Dept Urol Luoyang Peoples R China;

    Zhengzhou Univ Luoyang Cent Hosp Affiliated Dept Urol Luoyang Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

    Serine-arginine protein kinase 1 (SRPK1); Renal cell carcinoma (RCC); Invasion; PI3K/Akt pathway;

    机译：丝氨酸 - 精氨酸蛋白激酶1（SRPK1）;肾细胞癌（RCC）;入侵;PI3K / AKT路径;

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