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首页> 外文期刊>Ocular oncology and pathology. >Evidence of Tumour Microenvironment and Stromal Cellular Components in Retinoblastoma
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Evidence of Tumour Microenvironment and Stromal Cellular Components in Retinoblastoma

机译：视网膜细胞瘤中肿瘤微环境和基质细胞成分的证据

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Background: The tumour microenvironment (TME) consisting of tumour cells and multiple stromal cell types regulate tumour growth, invasion and metastasis. While the concept of TME and presence of stromal cellular components is widely established in cancers, its significance in the paediatric intraocular malignancy, retinoblastoma (RB), remains unknown. Methods: The study qualitatively identified the presence of multiple stromal cellular subtypes in RB TME by immunohistochemistry. Results: Results of the study identified the presence of stromal cell types such as endothelial cells, tumour-associated macrophages, fibroblasts, cancer-associated fibroblasts, retinal astrocytes and glia in RB TME. The extent of stromal marker positivity, however, did not correlate with histopathological features of RB. Conclusions: The findings of the study convincingly suggest the presence of a stromal component in RB tumours. The interactions between stromal cells and tumour cells might be of profound importance in RB progression.
机译：背景：由肿瘤细胞和多个基质细胞类型组成的肿瘤微环境（TME）调节肿瘤生长，侵袭和转移。虽然TME的概念和基质细胞成分的存在是在癌症中广泛建立的，但其在儿科人眼性恶性肿瘤视网膜母细胞瘤（RB）中的意义仍然未知。方法：该研究定性鉴定了免疫组化在RB TME中存在多种基质细胞亚型的存在。结果：该研究的结果确定了基质细胞类型，如内皮细胞，肿瘤相关的巨噬细胞，成纤维细胞，癌症相关的成纤维细胞，视网膜星形细胞和RB TME中的胶质细胞。然而，基质标志物阳性的程度与Rb的组织病理学特征无关。结论：研究结果令人信服地表明RB肿瘤中的基质成分存在。基质细胞和肿瘤细胞之间的相互作用在RB进展中可能具有深刻的重要性。

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