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首页> 外文期刊>Ophthalmic genetics >Role of the tissue-type plasminogen activator-7351C T and plasminogen activator inhibitor 1 4G/5G gene polymorphisms in central serous chorioretinopathy
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Role of the tissue-type plasminogen activator-7351C T and plasminogen activator inhibitor 1 4G/5G gene polymorphisms in central serous chorioretinopathy

机译：组织型纤溶酶原激活剂-7351C＆GT的作用; T和纤溶酶原激活剂抑制剂1 4g / 5g基因多态性在中枢性浆液性胆体胰蛋白病变

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Background: Central serous chorioretinopathy (CSC) is a common chorioretinal disease, characterized by choroidal hyperpermeability leading to neurosensory and/or retinal pigment epithelial detachments. Hypofibrinolysis due to higher plasma concentrations of plasminogen activator type 1 (PAI-1) or lower activity of tissue-type plasminogen activator (t-PA) has been implicated in the pathogenesis of CSC. Functional polymorphisms in the PAI-1 (SERPINE1) and t-Pa (PLAT) are thus potential risk factors for CSC. The aim of the present study was therefore to investigate a hypothesized association between the PAI-1 4G/5G and the t-PA -7351C T gene variants and the presence of CSC. Methods: The present study comprised 172 CSC patients and 313 control subjects. Genotypes of the PAI-1 4G/5G and the t-PA -7351C T polymorphisms were determined by TaqMan(TM) fluorogenic 5 '-exonuclease assays. Results: Allelic frequencies or genotype distributions of neither the PAI-1 4G/5G nor the t-PA -7531C T polymorphisms were significantly different between patients with CSC and control subjects (PAI-1 4G/4G: 24.4% vs. 20.4, p = 0.36; t-PA -7351CC: 42.4% vs. 46.0%, p = 0.50). After adjusting for age and gender presence of the PAI-1 4G/4G genotype was associated with a non-significant odds ratio (OR) of 1.21 (95% confidence interval [95% CI]: 0.77-1.92, p = 0.41), while homozygosity for the t-PA -7351C allele yielded a non-significant OR of 0.91 (95% CI: 0.62-1.33, p = 0.62) for CSC. Conclusion: The present study suggests that both the t-PA -7351C T and the PAI-1 4G/5G gene variants are unlikely major risk factors for CSC.
机译：背景：中央浆液性胆管胰蛋白病（CSC）是一种常见的脉络膜疾病，其特征在于脉络膜高血压性，导致神经感觉和/或视网膜颜料上皮脱离。由于较高的纤溶酶原激活剂型（PAI-1）或组织型纤溶酶原激活剂（T-PA）的较低活性引起的溶溶解型已经涉及CSC的发病机制。因此，PAI-1（Serpine1）和T-PA（平板）的功能多态性因此是CSC的潜在危险因素。因此，本研究的目的是研究PAI-1 4G / 5G和T-PA -7351C＆GT之间的假设相关联。 T基因变体和CSC的存在。方法：本研究组成172例CSC患者和313个对照受试者。 PAI-1 4G / 5G的基因型和T-PA -7351C＆GT; T多态性由Taqman（TM）荧光5' - 核酸酶测定法测定。结果：既不是PAI-1 4G / 5G也不是T-PA -7531C＆GT的等位基因频率或基因型分布。 CSC和对照受试者患者之间的多态性显着差异（PAI-1 4G / 4G：24.4％与20.4，P = 0.36; T-PA -7351CC：42.4％vs.46.0％，P = 0.50）。调整PAI-1 4G / 4G基因型的年龄和性别存在后，与1.21的非显着的差异比（或）（95％置信区间[95％CI]：0.77-1.92，P = 0.41）相关，虽然T-PA -7351C等位基因的纯合子，但CSC的非显着或0.91（95％CI：0.62-1.33，P = 0.62）。结论：本研究表明，T-PA -7351C＆GT; T和PAI-1 4G / 5G基因变体对于CSC来说是不太可能的主要危险因素。

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