RYGB Produces more Sustained Body Weight Loss and Improvement of Glycemic Control Compared with VSG in the Diet-Induced Obese Mouse Model

Hao Zheng; Townsend R. Leigh; Mumphrey Michael B.; Morrison Christopher D.; Munzberg Heike; Berthoud Hans-Rudolf

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RYGB Produces more Sustained Body Weight Loss and Improvement of Glycemic Control Compared with VSG in the Diet-Induced Obese Mouse Model

机译：与饮食诱导的肥胖小鼠模型中的VSG相比，RYGB产生更持续的体重减轻和血糖控制的改善

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Background Weight regain and type-2 diabetes relapse has been reported in a significant proportion of vertical sleeve gastrectomy (VSG) patients in some studies, but definitive conclusions regarding the long-term comparative effectiveness of VSG and Roux-en-Y gastric bypass (RYGB) surgery are lacking both in humans and rodent models. This study's objective was to compare the effects of murine models of VSG and RYGB surgery on body weight, body composition, food intake, energy expenditure, and glycemic control.

机译：背景技术重量恢复和类型2糖尿病复发已在一些研究中的垂直套管胃切除术（VSG）患者中，但有关VSG和ROUX-ZH-Y胃旁路的长期比较效果的明确结论（RYGB ）手术缺乏人类和啮齿动物模型。本研究的目的是比较VSG和RYGB手术的鼠模型对体重，身体成分，食物摄入，能源消耗和血糖控制的影响。

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来源
《Obesity surgery》 |2017年第9期|共10页
作者
Hao Zheng; Townsend R. Leigh; Mumphrey Michael B.; Morrison Christopher D.; Munzberg Heike; Berthoud Hans-Rudolf;
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作者单位

Louisiana State Univ Syst Pennington Biomed Res Ctr Neurobiol Nutr &

Metab Dept 6400 Perkins Rd;

Louisiana State Univ Syst Pennington Biomed Res Ctr Neurobiol Nutr &

Metab Dept 6400 Perkins Rd;

Louisiana State Univ Syst Pennington Biomed Res Ctr Neurobiol Nutr &

Metab Dept 6400 Perkins Rd;

Louisiana State Univ Syst Pennington Biomed Res Ctr Neurobiol Nutr &

Metab Dept 6400 Perkins Rd;

Louisiana State Univ Syst Pennington Biomed Res Ctr Neurobiol Nutr &

Metab Dept 6400 Perkins Rd;

Louisiana State Univ Syst Pennington Biomed Res Ctr Neurobiol Nutr &

Metab Dept 6400 Perkins Rd;

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原文格式 PDF
正文语种 eng
中图分类外科学;
关键词
Bariatric surgery; Body composition; Food intake; Fasting insulin; Weight regain; Energy expenditure; Metabolic adaptation;

机译：野生手术;身体成分;食物摄入;禁食胰岛素;重量恢复;能源支出;代谢适应;

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专利

1. RYGB Produces more Sustained Body Weight Loss and Improvement of Glycemic Control Compared with VSG in the Diet-Induced Obese Mouse Model [J] . Hao Zheng, Townsend R. Leigh, Mumphrey Michael B., Obesity surgery . 2017,第9期

机译：与饮食诱导的肥胖小鼠模型中的VSG相比，RYGB产生更持续的体重减轻和血糖控制的改善
2. Farnesoid X receptor contributes to body weight-independent improvements in glycemic control after Roux-en-Y gastric bypass surgery in diet-induced obese mice [J] . Kun Li, Jianan Zou, Song Li, Molecular Metabolism . 2020,第1期

机译：法呢X受体在饮食诱导的肥胖小鼠患者胃旁路手术后有助于血糖控制的体重互相改善
3. CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models [J] . Tharappel M Anil, Chandrashekaran Harish, Mudigere N Lakshmi, Cardiovascular Diabetology . 2014,第1期

机译：CNX-012-570，一种直接的AMPK激活剂，可提供强大的血糖和脂质控制能力，并显着减轻体重;饮食诱导的肥胖小鼠和db / db小鼠模型的研究
4. ZP2435 Decreases Body Weight Gain in Diet-Induced Obese Wistar Rats [C] . Lars Bo L. Hansen, Jens R. Daugaard American Peptide Symposium . 2011

机译：ZP2435降低饮食诱导的肥胖Wistar大鼠体重增加
5. The influence of diet-induced weight loss and aerobic exercise on skeletal muscle mass in obese older adults. [D] . Chomentowski, Peter Joseph, 3rd. 2007

机译：饮食诱导的减肥和有氧运动对肥胖老年人的骨骼肌质量的影响。
6. RYGB produces more sustained body weight loss and improvement of glycemic control compared with VSG in the diet-induced obese mouse model [O] . Zheng Hao, R. Leigh Townsend, Michael B Mumphrey, -1

机译：在饮食诱导的肥胖小鼠模型中RYGB与VSG相比可产生更持续的体重减轻并改善血糖控制
7. CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models [O] . Tharappel M Anil, Chandrashekaran Harish, Mudigere N Lakshmi, 2014

机译：CNX-012-570，一种直接的AMPK激活剂，可提供强大的血糖和脂质控制能力，并显着减轻体重；饮食诱导的肥胖小鼠和db / db小鼠模型的研究

RYGB Produces more Sustained Body Weight Loss and Improvement of Glycemic Control Compared with VSG in the Diet-Induced Obese Mouse Model

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