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首页> 外文期刊>Oral diseases >Influence of Porphyromonas gingivalis Porphyromonas gingivalis in gut microbiota of streptozotocin‐induced diabetic mice
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Influence of Porphyromonas gingivalis Porphyromonas gingivalis in gut microbiota of streptozotocin‐induced diabetic mice

机译：链脲佐菌素诱导的糖尿病小鼠肠道微生物卟啉孢子的影响

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摘要

Abstract Objectives Increasing evidence suggests that periodontitis can exacerbate diabetes, and gut bacterial dysbiosis appears to be linked with the diabetic condition. The present study examined the effects of oral administration of the periodontopathic bacterium, Porphyromonas gingivalis , on the gut microbiota and systemic conditions in streptozotocin‐induced diabetic mice. Materials and Methods Diabetes was induced by streptozotocin injection in C57BL/6J male mice (STZ). STZ and wild‐type (WT) mice were orally administered P.?gingivalis (STZPg, WTPg) or saline (STZco, WTco). Feces were collected, and the gut microbiome was examined by 16S rRNA gene sequencing. The expression of genes related to inflammation, epithelial tight junctions, and glucose/fatty acid metabolism in the ileum or liver were examined by quantitative PCR. Results The relative abundance of several genera, including Brevibacterium , Corynebacterium , and Facklamia, was significantly increased in STZco mice compared to WTco mice. The relative abundances of Staphylococcus and Turicibacter in the gut microbiome were altered by oral administration of P.?gingivalis in STZ mice. STZPg mice showed higher concentrations of fasting blood glucose and inflammatory genes levels in the ileum, compared to STZco mice. Conclusions Oral administration of P.?gingivalis altered the gut microbiota and aggravated glycemic control in streptozotocin‐induced diabetic mice.
机译：摘要目的越来越多的证据表明，牙周炎可以加剧糖尿病，肠道细菌脱泻病似乎与糖尿病​​病症相关联。本研究检测了口服牙科病变，卟啉核苷酸卟啉基团，牙龈微生物，肠道微生物菌和糖尿病诱导的糖尿病小鼠中的全身状况的影响。通过链脲佐菌素注射在C57BL / 6J雄性小鼠（STZ）中诱导材料和方法糖尿病。 STZ和野生型（WT）小鼠是口服给药的p.?gingivalis（Stzpg，WTPG）或盐水（STZCO，WTCO）。收集粪便，通过16S rRNA基因测序检查肠道微生物组。通过定量PCR检查与炎症，上皮紧密交界和血糖或肝脏中血糖/脂肪酸代谢相关的基因的表达。结果与WTCO小鼠相比，STZCO小鼠的几种属的相对丰度在内的糖尿病，包括棒状杆菌和Facklamia显着增加。通过口服施用肠道微生物组中的葡萄球菌和TURICIBARABRACT的相对丰度通过口服给药。与STZCO小鼠相比，Stzpg小鼠显示了回肠中的浓度更高的空腹血糖和炎症基因水平。结论P.Ingivalis的口服施用改变了肠道微生物肿瘤和加重血糖诱导的糖尿病小鼠的加重血糖对照。

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  • 来源
    《Oral diseases》 |2019年第3期|共13页
  • 作者

    Ohtsu Anri; Takeuchi Yasuo; Katagiri Sayaka; Suda Wataru; Maekawa Shogo; Shiba Takahiko; Komazaki Rina; Udagawa Sayuri; Sasaki Naoki; Hattori Masahira; Izumi Yuichi;

  • 作者单位

    Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and;

    Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and;

    Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and;

    RIKEN Center for Integrative Medical SciencesYokohama Japan;

    Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and;

    Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and;

    Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and;

    Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and;

    Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and;

    RIKEN Center for Integrative Medical SciencesYokohama Japan;

    Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 口腔科学;
  • 关键词

    gut microbiota; periodontitis; streptozotocin;

    机译：肠道微生物;牙周炎;链脲佐菌素;

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