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TGF-β signaling in intervertebral disc health and disease

机译：椎间盘健康和疾病中的TGF-β信号传导

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Objective: This paper aims to provide a comprehensive review of the changing role of transforming growth factor-beta (TGF-β) signaling in intervertebral disc (IVD) health and disease. Methods: A comprehensive literature search was performed using PubMed terms 'TGF-β' and 'IVD'. Results: TGF-β signaling is necessary for the development and growth of IVD, and can play a protective role in the restoration of IVD tissues by stimulating matrix synthesis, inhibiting matrix catabolism, inflammatory response and cell loss. However, excessive activation of TGF-β signaling is detrimental to the IVD, and inhibition of the aberrant TGF-β signaling can delay IVD degeneration. Conclusions: Activation of TGF-β signaling has a promising treatment prospect for IVD degeneration, while excessive activation of TGF-β signaling may contribute to the progression of IVD degeneration. Studies aimed at elucidating the changing role of TGF-β signaling in IVD at different pathophysiological stages and its specific molecular mechanisms are needed, and these studies will contribute to safe and effective TGF-β signaling-based treatments for IVD degeneration.
机译：目的：本文旨在全面审查转化生长因子-β（TGF-β）信号传导在椎间盘（IVD）健康和疾病中的作用的变化。方法：使用PubMed术语“TGF-β”和“IVD”进行全面的文献搜索。结果：TGF-β信令是IVD的发展和生长所必需的，并且通过刺激基质合成，抑制基质分解代谢，炎症反应和细胞损失，可以在恢复IVD组织中发挥保护作用。然而，TGF-β信令的过度激活对IVD有害，并且对异常TGF-β信号传导的抑制可以延迟IVD变性。结论：TGF-β信号传导的激活具有IVD变性的有希望的治疗前景，而TGF-β信号传导的过度激活可能有助于IVD变性的进展。需要研究在不同病理生理阶段的IVD中阐明TGF-β信令的变化变化及其特定分子机制，并且这些研究将有助于IVD变性的安全有效的TGF-β信号传导的处理。

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