Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles

Akhbari P.; Jaggard M. K.; Boulange C. L.; Vaghela U.; Graca G.; Bhattacharya R.; Lindon J. C.; Williams H. R. T.; Gupte C. M.

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Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles

机译：骨关节炎髋关节和膝关节滑膜组成的差异：代谢谱的核磁共振（NMR）光谱研究

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Objective: The hip and knee joints differ biomechanically in terms of contact stresses, fluid lubrication and wear patterns. These differences may be reflected in the synovial fluid (SF) composition of the two joints, but the nature of these differences remains unknown. The objective was to identify differences in osteoarthritic hip and knee SF metabolites using metabolic profiling with Nuclear Magnetic Resonance (NMR) spectroscopy.

机译：目的：髋关节和膝关节在接触应力，流体润滑和磨损图案方面有不同的影响。这些差异可以反映在两个关节的滑膜液（SF）组合物中，但这些差异的性质仍然未知。目的是利用核磁共振（NMR）光谱法鉴定骨关节炎髋关节和膝关节SF代谢物的差异。

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来源
《Osteoarthritis and cartilage》 |2019年第12期|共10页
作者
Akhbari P.; Jaggard M. K.; Boulange C. L.; Vaghela U.; Graca G.; Bhattacharya R.; Lindon J. C.; Williams H. R. T.; Gupte C. M.;
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作者单位

Imperial Coll Healthcare NHS Trust Dept Orthopaed &

Trauma London England;

Imperial Coll Healthcare NHS Trust Dept Orthopaed &

Trauma London England;

Imperial Coll Healthcare NHS Trust Dept Digest Dis London England;

Imperial Coll London Dept Metab Digest &

Reprod London England;

Imperial Coll Healthcare NHS Trust Dept Digest Dis London England;

Imperial Coll Healthcare NHS Trust Dept Orthopaed &

Trauma London England;

Imperial Coll Healthcare NHS Trust Dept Digest Dis London England;

Imperial Coll London Sch Med London England;

Imperial Coll Healthcare NHS Trust Dept Orthopaed &

Trauma London England;

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正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Metabolic profiling; Metabonomics; NMR; Osteoarthritis; Synovial fluid;

机译：代谢分析;代谢型;NMR;骨关节炎;滑膜;

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专利

1. Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles [J] . Akhbari P., Jaggard M. K., Boulange C. L., Osteoarthritis and cartilage . 2019,第12期

机译：骨关节炎髋关节和膝关节滑膜组成的差异：代谢谱的核磁共振（NMR）光谱研究
2. 1H-Nuclear Magnetic Resonance Studies of Human Synovial Fluid in Arthritic Disease States as An Aid to Confirming Metabolic Activity in the Synovial Cavity [J] . B. Walker, D. J. S. Guthrie, E. Walsh, Clinical Science . 1993,第3期

机译：1H核磁共振研究关节炎疾病状态下人滑液的作用，以帮助确认滑膜腔中的代谢活性
3. 1H-Nuclear Magnetic Resonance Studies of Human Synovial Fluid in Arthritic Disease States as An Aid to Confirming Metabolic Activity in the Synovial Cavity [J] . B. Walker, D. J. S. Guthrie, E. Walsh, Clinical Science . 1993,第3期

机译：1H核磁共振研究关节炎疾病状态下人滑液的作用，以帮助确认滑膜腔中的代谢活性
4. METABOLIC PROFILES OF MULTICENTRIC CANINE LYMPHOMA BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY [C] . Susan Kraft, Susan Lana, Annette Bachand, Annual Conference of the Veterinary Cancer Society . 2009

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5. Metabolomics of Stress: Assessing Bio-Fluids in Rats and Humans using Proton Nuclear Magnetic Resonance (1H NMR) Spectroscopy [D] . Paxman, Eric James. 2018

机译：应激的代谢组学：使用质子核磁共振（1H NMR）光谱法评估大鼠和人体中的生物流体
6. Characterization of lipid profile by nuclear magnetic resonance spectroscopy (1H NMR) of metabolically healthy obese women after weight loss with Mediterranean diet and physical exercise [O] . Enrique Rodriguez-Garcia, Josefina Ruiz-Nava, Sonia Santamaria-Fernandez, -1

机译：通过地中海饮食和体育锻炼减肥后代谢健康的肥胖女性的核磁共振波谱（1H NMR）表征脂质分布
7. Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles [O] . P. Akhbari, M.K. Jaggard, C.L. Boulangé, 2019

机译：骨关节炎髋关节和膝关节滑膜组成的差异：代谢谱的核磁共振（NMR）光谱研究

Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles

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