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首页> 外文期刊>Schizophrenia bulletin >Utilizing Mutual Information Analysis to Explore the Relationship Between Gray and White Matter Structural Pathologies in Schizophrenia
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Utilizing Mutual Information Analysis to Explore the Relationship Between Gray and White Matter Structural Pathologies in Schizophrenia

机译：利用互信息分析探讨精神分裂症灰白质结构病理学的关系

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Schizophrenia has been characterized as a neurodevelopmental disorder, with structural brain abnormalities reported at all stages. However, at present, it remains unclear whether gray and white matter abnormalities represent related or independent pathologies in schizophrenia. In this study, we present findings from an integrative analysis exploring the morphological relationship between gray and white matter in 45 schizophrenia participants and 49 healthy controls. We utilized mutual information (MI), a measure of how much information two variables share, to assess the morphological dependence between gray and white matter in three segments of the corpus callsoum, and the gray matter regions these segments connect: (1) the genu and the left and right rostral middle frontal gyrus (rMFG), (2) the isthmus and the left and right superior temporal gyrus (STG), (3) the splenium and the left and right lateral occipital gyrus (LOG). We report significantly reduced MI between white matter tract dispersion of the right hemispheric callosal connections to the STG and both cortical thickness and area in the right STG in schizophrenia patients, despite a lack of group differences in cortical thickness, surface area, or dispersion. We believe that this reduction in morphological dependence between gray and white matter may reflect a possible decoupling of the developmental processes that shape morphological features of white and gray matter early in life. The present study also demonstrates the importance of studying the relationship between gray and white matter measures, as opposed to restricting analyses to gray and white matter measures independently.
机译：精神分裂症的特征是神经发育障碍，具有各阶段的结构脑异常。然而，目前，仍然不清楚灰色和白质异常是否代表精神分裂症中的相关或独立病症。在这项研究中，我们从综合分析中展示了45名精神分裂症参与者和49名健康对照中灰白质与白土之间的形态关系的结果。我们利用了互信息（MI），衡量两个变量共享的数量，评估灰色和白质之间的形态依赖性在语料库CALLOUM的三个区段中，灰质地区这些段连接：（1）正常和左右升振射压的中正面 - （RMFG），（2）斯蒂姆和左右颞末颞克鲁（STG），（3）脾脏和左侧和右侧枕骨（LOG）。我们报告了在精神分裂症患者的STG右半球调用连接的白质愈伤组织连接的白质子愈伤组织连接与STG中的皮质厚度和面积之间的显着减少了MI，尽管皮质厚度，表面积或分散体缺乏组分差异。我们认为，灰色和白质之间的形态依赖的降低可能反映了在生活中早期形状的形成过程的发育过程的可能去耦。本研究还展示了研究灰色和白质措施之间关系的重要性，而不是独立地限制对灰色和白质措施的分析。

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