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首页> 外文期刊>Science and engineering ethics >Systematic Assessment of Research on Autism Spectrum Disorder (ASD) and Mercury Reveals Conflicts of Interest and the Need for Transparency in Autism Research (Retracted article. See vol. 23, pg. 1689, 2017)
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Systematic Assessment of Research on Autism Spectrum Disorder (ASD) and Mercury Reveals Conflicts of Interest and the Need for Transparency in Autism Research (Retracted article. See vol. 23, pg. 1689, 2017)

机译：系统评估自闭症谱系障碍（ASD）和汞的研究揭示了利益冲突和自闭症研究中透明度的需求（缩回的文章。见Vol.23，PG。1689,2017）

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Historically, entities with a vested interest in a product that critics have suggested is harmful have consistently used research to back their claims that the product is safe. Prominent examples are: tobacco, lead, bisphenol A, and atrazine. Research literature indicates that about 80-90% of studies with industry affiliation found no harm from the product, while only about 10-20% of studies without industry affiliation found no harm. In parallel to other historical debates, recent studies examining a possible relationship between mercury (Hg) exposure and autism spectrum disorder (ASD) show a similar dichotomy. Studies sponsored and supported by industry or entities with an apparent conflict of interest have most often shown no evidence of harm or no "consistent" evidence of harm, while studies without such affiliations report positive evidence of a Hg/autism association. The potentially causal relationship between Hg exposure and ASD differs from other toxic products since there is a broad coalition of entities for whom a conflict of interest arises. These include influential governmental public health entities, the pharmaceutical industry, and even the coal burning industry. This review includes a systematic literature search of original studies on the potential relationship between Hg and ASD from 1999 to August 2015, finding that of the studies with public health and/or industry affiliation, 86% reported no relationship between Hg and ASD. However, among studies without public health and/or industry affiliation, only 21% find no relationship between Hg and ASD. The discrepancy in these results suggests a bias indicative of a conflict of interest.
机译：从历史上看，批评者建议的产品具有既得利益有害的实体一直使用研究以支持产品是安全的。突出的例子是：烟草，铅，双酚A和尿嘧啶。研究文献表明，大约80-90％的行业联盟研究发现了该产品的伤害，而没有行业轴关的研究只有大约10-20％的研究发现没有危害。与其他历史辩论平行，最近的研究检查了汞（HG）暴露和自闭症谱系（ASD）之间可能的关系显示出类似的二分法。由行业或实体赞助和支持具有明显利益冲突的研究最常见的是没有危害的证据或没有“一致”的危害证据，而没有此类附属机构的研究报告了HG /自闭症协会的积极证据。 Hg曝光和ASD之间的潜在因果关系与其他有毒产品不同，因为有一个广泛的实体联盟，它出现了利益冲突。其中包括有影响力的政府公共卫生实体，制药行业，甚至是煤炭燃烧行业。该综述包括对1999年至2015年8月至2015年8月的HG和ASD之间的潜在关系的系统文献搜索，发现公共卫生和/或行业隶属关系的研究，86％报告了HG和ASD之间的关系。然而，在没有公共卫生和/或行业义务的研究中，只有21％的人发现HG和ASD之间没有任何关系。这些结果的差异表明偏见指示利益冲突。

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