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首页> 外文期刊>Russian journal of electrochemistry >Synthesis, Characterization, in vitro Antifungal Activities and Calf Thymus DNA Interactions of Two Different Hydroxy Benzaldehyde Derivative Schiff Bases from Sulfamethizole: Electrochemical, Spectroscopic and Biological Study
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Synthesis, Characterization, in vitro Antifungal Activities and Calf Thymus DNA Interactions of Two Different Hydroxy Benzaldehyde Derivative Schiff Bases from Sulfamethizole: Electrochemical, Spectroscopic and Biological Study

机译：两种不同羟基苯甲醛衍生物Schiff基碱来自巯基甲唑的合成，表征，体外抗真菌活性和小牛胸腺DNA相互作用：电化学，光谱和生物学研究

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摘要

In the present work, the Schiff bases were synthesized by reacting sulfamethizole (SMTZ) with two different hydroxy benzaldehydes (2,3-dihydroxy benzaldehyde (DHBA) and 2,4,6-trihydroxy benzaldehyde (THBA)) and characterized by elemental analysis, H-1-NMR and IR spectroscopies. From the obtained data, it was suggested that 4,6-dihydroxy salicylaldehyde reacted with both primary and secondary amine groups of SMTZ. The binding properties between the synthesized Schiff bases and calf thymus DNA (CT-DNA) at the physiological pH (7.4) was investigated by using cyclic voltammetry and UV-Vis spectroscopy techniques. The experimental results verify that the Schiff bases can bind to CT-DNA by electrostatic mode in 1 : 1 stoichiometry. Antifungal activities of the synthesized Schiff bases against Candida albicans ATCC 10231 were studied and their minimum inhibitory concentrations (MIC) were also determined. The MIC value of the Schiff base 1 synthesized from DHBA is smaller than that of the Schiff base 2 obtained from THBA. Although Schiff base 2 binds to CT-DNA with a higher affinity than Schiff base 1, it is less effective than Schiff base 1 against Candida albicans.
机译：在本作本作中，通过使磺胺甲酚（SMTZ）与两种不同的羟基苯甲醛（2,3-二羟基苯甲苯胺（DHBA）和2,4,6-三羟基苯苯甲醛（THBA）反应合成Schiff碱基，并通过元素分析， H-1-NMR和IR光谱。从获得的数据中，建议4,6-二羟基水杨醛与SMTZ的初级和仲胺基团反应。通过使用循环伏安法和UV-VI光谱技术研究了在生理pH（7.4）处的合成席克碱基和小牛胸腺DNA（CT-DNA）之间的结合特性。实验结果验证了席克群可以通过静电模式在1：1化学计量中与CT-DNA结合。研究了合成的Schiff碱基抗念珠菌ATCC 10231的抗真菌活性，并确定了它们的最小抑制浓度（MIC）。从DHBA合成的Schiff底座1的MIC值小于从THBA获得的SCHIFF底座2的MIC值。虽然Schiff Base 2与比Schiff Base 1更高的亲和力与CT-DNA结合，但它比Schiff Base 1对抗Candida albicans的亲和力较小。

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