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首页> 外文期刊>BJU international >Hybrid tumour 'oncocytoma-chromophobe renal cell carcinoma' of the kidney: a report of seven sporadic cases.
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Hybrid tumour 'oncocytoma-chromophobe renal cell carcinoma' of the kidney: a report of seven sporadic cases.

机译：肾脏的混合型肿瘤“嗜铬细胞瘤肾细胞癌”：七例散发病例的报告。

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OBJECTIVES: To determine whether renal hybrid tumours (HT) appear as a specific clinical and radiological entity, as HT are characterized by the association of both oncocytes and chromophobe cells within the same tumour, and have been described in patients with oncocytosis and Birt-Hogg-Dube syndrome. PATIENTS AND METHODS: We reviewed the medical charts of 67 patients who had a partial or radical nephrectomy in our institution for renal oncocytoma (RO, 24), chromophobe renal cell carcinoma (CRCC, 36) and HT (seven), from January 2006 to October 2007. We report the clinical, radiological and pathological characteristics of the seven cases of HT. RESULTS: The mean (range) age of the patients was 56 (41-68) year. None of the seven patients had any suspicion of RO, based on computed tomography (CT). Two patients had a history of kidney cancer. Five patients had partial and two a radical nephrectomy. The mean (range) maximum tumour diameter was 5.5 (1.8-9) cm. Two tumours were pT1a, two were pT1b and three were pT2. Pathological analysis showed RO-like and CRCC-like cells intermixed (six patients) or distinct (one). After a median (range) follow-up of 20 (8-25) months, none of the patients had any evidence of disease recurrence. CONCLUSIONS: In a large series of patients with sporadic RO and CRCC, 10% of the tumours had hybrid morphological features, as described in oncocytosis and Birt-Hogg-Dube syndrome. We were unable to identify any specific clinical characteristic. Most importantly, none of these HT showed any of the radiological characteristics of RO.
机译：目的：为了确定肾脏杂种肿瘤（HT）是否表现为特定的临床和放射学实体，因为HT的特征是同一肿瘤内的癌细胞和生色细胞之间的关联，并且已在患有细胞吞噬和Birt-Hogg的患者中进行了描述-杜贝综合症。病人与方法：我们回顾了2006年1月至2006年1月间在我院进行的67例接受部分或根治性肾切除术的患者的病历，这些患者因肾上皮细胞瘤（RO，24），发色肾细胞癌（CRCC，36）和HT（7） 2007年10月。我们报告了7例HT的临床，影像学和病理学特征。结果：患者的平均（范围）年龄为56（41-68）岁。根据计算机断层扫描（CT），这7例患者均未怀疑RO。两名患者有肾癌病史。五例患者接受了部分肾切除术，二例接受了根治性肾切除术。平均（范围）最大肿瘤直径为5.5（1.8-9）cm。两个肿瘤是pT1a，两个是pT1b，三个是pT2。病理分析显示，RO样和CRCC样细胞混合在一起（六例）或不同（一个）。在中位（范围）随访20（8-25）个月后，没有患者有任何疾病复发的迹象。结论：在散发性RO和CRCC的大量患者中，有10％的肿瘤具有混合形态学特征，如Oncocytosis和Birt-Hogg-Dube综合征中所述。我们无法确定任何特定的临床特征。最重要的是，这些HT均未显示出RO的任何放射学特征。

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