• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular Neurobiology >Elevated Serum Levels of Neopterin at Admission Predicts Depression After Acute Ischemic Stroke: a 6-Month Follow-Up Study
【24h】

Elevated Serum Levels of Neopterin at Admission Predicts Depression After Acute Ischemic Stroke: a 6-Month Follow-Up Study

机译：在急性缺血性卒中后，入学后，血清Neopterin的血清水平升高预测：一个为期6个月的后续研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Inflammation and cell-mediated immune activation are attributed to the pathogenesis and pathophysiology in depression. Our aim was to test the possible association between serum levels of neopterin and the development of post-stroke depression (PSD) in Chinese patients. The subjects were first-ever acute ischemic stroke patients who were hospitalized at the First Affiliated Hospital of Xinxiang Medical University during the period from December 2012 to December 2013. Clinical information and stroke severity were collected at admission. Neurological and neuropsychological evaluations were conducted at the 6-month follow-up. Serum neopterin levels were measured using fluorometry and a high performance liquid chromatography (HPLC) method. Multivariate analyses were performed using logistic regression models. During the study period, 226 patients were included and finished the 6-month follow-up. Sixty-nine patients (30.5 %) were diagnosed as having major depression at 6 months. Patients with major depression showed higher levels of serum neopterin (21.6[IQR, 18.9-25.7]nmol/L vs. 14.6[IQR, 12.2-18.4]nmol/L, P < 0.0001) at admission. In multivariate analyses, serum neopterin was an independent predictor of PSD at 6 months [odds ratio (OR): 1.952 (95 % CI, 1.358-2.805), P < 0.0001]. With an AUC of 0.850 (95 % CI, 0.797-0.902), neopterin showed a significantly greater discriminatory ability as compared with high-sensitivity C-reactive protein, age, body mass index, and National Institutes of Health and Stroke Scale score. Neopterin is a novel, independent predictor of the development of depression 6 months after stroke. This indicated that the elevated neopterin levels may play a significant role in the pathology of depression and that the pathways leading to inflammation and cell-mediated immune activation warrant further exploration.
机译：炎症和细胞介导的免疫活化归因于抑郁症的发病机制和病理生理学。我们的目的是测试中国患者中血清血清水平与中风后抑郁（PSD）的可能关联。该受试者是在2012年12月至2013年12月期间在新乡医科大学附属大学附属医院住院的首次急性缺血性脑卒中患者。临床信息和卒中严重程度在入场时收集。在6个月的随访中进行了神经系统和神经心理学评估。使用荧光术和高效液相色谱（HPLC）方法测量血清新型水平。使用Logistic回归模型进行多变量分析。在研究期间，包括226名患者并完成了6个月的随访。六十九名患者（30.5％）被诊断为6个月患有重大抑郁症。主要抑郁症患者显示出较高水平的血清Neopterin（21.6 [IQR，18.9-25.7] Nmol / L与14.6 [IQR，12.2-18.4] Nmol / L，P <0.0001）。在多变量分析中，血清Neopterin是PSD的独立预测因子，在6个月（O或）：1.952（95％CI，1.358-2.805），P <0.0001]。含有0.850（95％CI，0.797-0.902）的AUC，与高敏感性C反应蛋白，年龄，体重指数和国家健康研究院和中风比例相比，Neopterin显示出明显更大的歧视能力。 Neopterin是一种小说，卒中后6个月的抑郁症的发展。这表明隆起率升高可能在抑郁病理学中发挥重要作用，并且导致炎症和细胞介导的免疫激活的途径进一步探索。

著录项

  • 来源
    《Molecular Neurobiology》 |2016年第5期|共11页
  • 作者

    Tang Chao-Zhi; Zhang Yu-Ling; Wang Wen-Sheng; Li Wei-Guo; Shi Ji-Peng;

  • 作者单位

    Henan Normal Univ Coll Life Sci Mol Med Lab 46 Jianshedong Rd Xinxiang 453007 Henan Province;

    Henan Normal Univ Coll Life Sci Mol Med Lab 46 Jianshedong Rd Xinxiang 453007 Henan Province;

    Henan Normal Univ Coll Life Sci Mol Med Lab 46 Jianshedong Rd Xinxiang 453007 Henan Province;

    Henan Normal Univ Coll Life Sci Mol Med Lab 46 Jianshedong Rd Xinxiang 453007 Henan Province;

    Xinxiang Med Univ Affiliated Hosp 1 Xinxiang Henan Province Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 人体生理学;
  • 关键词

    Neopterin; Acute ischemic stroke; Depression; Chinese;

    机译：Neopterin;急性缺血性卒中;抑郁症;中文;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号