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首页> 外文期刊>Seminars in Nephrology >Female Adolescents with Chronic or End-Stage Kidney Disease and Strategies for their Care
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Female Adolescents with Chronic or End-Stage Kidney Disease and Strategies for their Care

机译：雌性青少年患有慢性或末期肾病和他们的护理策略

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Summary: The prevalence of chronic or end-stage kidney disease in pediatric girls is lower than in boys, however, girls have unique morbidities that can have great effect on their quality of life. For female adolescents, creatinine excretion peaks at approximately 14 years of age and is significantly less than males, owing to lower muscle mass. Females have higher nitric oxide activity, and estrogens may contribute to lower blood pressure. Females excrete less growth hormone during the prepubertal and pubertal years. Females between the ages of 8 and 10 years show increased levels of parathyroid hormone and vitamin D, however, female adolescents with chronic kidney disease have less estrogen and loss of the luteinizing hormone pulsatile pattern. These biological, hormonal, and physical changes affect the psychosocial aspects of female adolescents with chronic kidney disease/end-stage kidney disease, and they must learn to manage their health to achieve good outcomes. Patients and their parents must learn disease management through a customized health care transition preparation in both the pediatric- and adult-focused settings. Clinical strategies are suggested for the care of these special patients.
机译：摘要：儿科女孩慢性或末期肾病的患病率低于男孩，但是，女孩具有独特的病态，对他们的生活质量有很大影响。对于雌性青少年，由于较低的肌肉质量，肌酐排泄大约14岁的峰值，并且显着少于雄性。女性具有较高的一氧化氮活性，并且雌激素可能有助于降低血压。女性在预增生和青春期多年期间排泄较少的生长激素。 8和10年代之间的女性显示甲状旁腺激素和维生素D水平增加，然而，慢性肾病的雌性青少年具有较少的雌激素和叶黄素激素脉动图案的损失。这些生物学，激素和物理变化影响了慢性肾病/末期肾病的雌性青少年的心理社会方面，他们必须学会管理他们的健康，以实现良好的结果。患者及其父母必须通过在儿科和成人集体的环境中通过定制的医疗过渡准备来学习疾病管理。为这些特殊患者提供临床策略。

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