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Expanding the Role for Kidney Biopsies in Acute Kidney Injury

机译:扩大肾脏活检在急性肾损伤中的作用

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Summary: Acute kidney injury (AKI) is a highly heterogeneous, common, and potentially devastating condition associated with markedly increased hospital length of stay, cost, mortality, and morbidity. Expanding the role for kidney biopsies in AKI may offer fresh insights into disease heterogeneity, molecular mechanisms, and therapeutic targets. A number of challenges face investigators and clinicians considering research biopsies in AKI: ensuring patient safety, ensuring the ethical conduct of research studies, and maximizing the scientific yield of the kidney tissue obtained. The societal benefits of research that lead to novel strategies for preventing and treating AKI would be enormous. Rethinking our current approach to the role of kidney biopsy for AKI diagnosis and research may be a major step toward the promise of personalized medicine in nephrology.
机译:发明内容:急性肾损伤(AKI)是一种高度异质,常见的,潜在的毁灭性条件,与医院的住宿,成本,死亡率和发病率显着增加。 扩大AKI中肾脏活检的作用可能会对疾病异质性,分子机制和治疗靶标提供新的洞察力。 考虑AKI的研究活检的一些挑战人员对研究活检的挑战:确保患者的安全性,确保研究研究的道德行为,并最大化所获得的肾组织的科学产量。 导致预防和治疗AKI的新战略的研究的社会效益将是巨大的。 重新思考我们目前对肾脏活检对AKI诊断和研究作用的方法可能是朝着肾脏的个性化医学承诺的重要一步。

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