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首页> 外文期刊>Seminars in ophthalmology >Responses of Types 1 and 2 Neovascularization in Age-Related Macular Degeneration to Anti-Vascular Endothelial Growth Factor Treatment: Optical Coherence Tomography Angiography Analysis
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Responses of Types 1 and 2 Neovascularization in Age-Related Macular Degeneration to Anti-Vascular Endothelial Growth Factor Treatment: Optical Coherence Tomography Angiography Analysis

机译：年龄相关黄斑变性对抗血管内皮生长因子治疗的1和2种和2种新生血管化的反应：光学相干断层造影血管造影分析

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Purpose: To compare the responses of types 1 (sub-pigment epithelial) and 2 (subretinal) neovascularization in neovascular age-related macular degeneration (AMD) to anti-vascular endothelial growth factor (VEGF) treatment.Methods: Fifty-five treatment-naive neovascular AMD eyes (53 patients) were retrospectively included for analysis. All patients were treated with three loading injections of anti-VEGF agent, followed by further injections as required. The lesion size and vascular density of type 1 and 2 lesions before and after treatment for 12 months were analyzed using optical coherence tomography angiography (OCTA).Results: The mean lesion size of the type 1 neovascularization group (42 eyes) showed no significant change from 2.12 1.01 mm(2) at baseline to 2.08 +/- 0.91 mm(2) at 12 months (P = .682). However, the mean lesion size of type 2 neovascularization significantly decreased from 1.23 +/- 0.93 mm(2) at baseline to 0.79 +/- 0.61 mm(2) at 12 months (P = .022). The proportion of eyes with lesion sizes that decreased by more than 40% from baseline was also significantly higher for the type 2 compared to the type 1 neovascularization group (46.2% versus 11.9%, P = .007). Vascular density showed no significant changes for both groups after treatment and showed no association with the change in lesion size. There was no significant difference between the groups in terms of visual acuity improvement.Conclusion: OCTA analysis revealed different responses to anti-VEGF treatment depending on the location of neovascularization in neovascular AMD. Type 2 neovascularization was significantly regressed compared to type 1 neovascularization after anti-VEGF treatment. However, the changes in vascular density and visual outcome showed no significant differences between groups after 12 months of treatment.
机译：目的：将1（亚颜料上皮）和2（亚阈状）新血管形成在新生血管时代相关的黄斑（AMD）的反应进行比较，以抗血管内皮生长因子（VEGF）治疗。方法：五十五个治疗 - 犹豫的新生血管AMD眼睛（53名患者）被回顾性分析。所有患者均采用三次加入注射抗VEGF试剂治疗，然后根据需要进一步注射。使用光学相干断层血管造影（OctA）分析了1型和2型病变的病变尺寸和血管密度。结果：结果：1型新生血管或42只眼睛）的平均病变大小显示出没有显着变化从2.12 1.01 mm（2）在基线下，12个月以2.08 +/- 0.91 mm（2）（p = .682）。然而，2型新血管形成的平均病变大小从1.23 +/- 0.93mm（2）在12个月内以1.23 +/- 0.93mm（2）显着降低至0.79 +/- 0.61mm（2）（p = .022）。与基线从基线降低超过40％的病变尺寸的比例也与1型新生血管形成组相比也显着更高（46.2％对11.9％，P = .007）。血管密度对治疗后的两组没有显着变化，并且没有与病变大小的变化结合。在视力改善方面，组之间没有显着差异。结论：Octa分析根据新生血管AMD的新血管化位置显示对抗VEGF处理的不同反应。与抗VEGF处理后1型新血管形成相比，2型新血管形成显着回归。然而，血管密度和视觉结果的变化显示在治疗12个月后组之间没有显着差异。

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