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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Personalized goal for insomnia and clinical response in advanced cancer patients
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Personalized goal for insomnia and clinical response in advanced cancer patients

机译：高症癌症患者失眠和临床反应的个性化目标

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Aim The aim of this study was to assess the Personalized Insomnia Intensity Goal (PIIG), the achievement of Personalized Goal Response (PGR), and Patient Global Impression (PGI) after a comprehensive symptom management. Patients and methods Advanced cancer patients admitted to palliative care units rated pain and symptoms intensity and their PIIG by using the Edmonton Symptom Assessment Score (ESAS) (T0). In patients with significant levels of insomnia, the achievement of target expected (PIIG) was measured (patient goal response, PIGR), as well the patient global impression (PGI), by the minimal clinically important difference (MCID), after a comprehensive symptom management (T7). Results Three hundred ninety-seven patients with a level of insomnia of >= 3 on ESAS were analyzed in this study. The mean values of PIIG at T0 and T7 were 1.2 (SD 1.5) and 0.9 (SD 1.4), respectively. Most patients (n = 406, 89.8%) indicated a PIIG of <= 3 as a target at T0. Such target was significantly lower at T7 (p = < 0.0005). PGI, expressed as MCID, was perceived with a mean decrease in insomnia intensity of - 2.3. In a minority of patients (n = 26; 5.8%) insomnia worsened, with a MCID of 0.50 (SD 2.8). Higher insomnia intensity at T0 and lower insomnia intensity at T7 were independently related to PGI. PIGR was achieved in 87.9% of patients. PIGR was associated with PIIG at T0, and inversely associated to insomnia intensity at T0 and T7, and PIIG at T7. Conclusion PGIR and PGI seem to be relevant for evaluating the effects of a comprehensive management of insomnia, suggesting therapeutic decisions according to PIIG. Some factors influencing the individual target and clinical response have been detected.
机译：目的这项研究的目的是评估个性化失眠强度目标（PIIG），在全面的症状管理后实现个性化目标反应（PGR）和患者全球印象（PGI）。患者和方法先进的癌症患者通过使用Edmonton症状评估评分（ESAs）（T0），进入姑息治疗单位的痛苦和症状强度及其PIIG。在患有显着性失眠水平的患者中，测量预期的目标预期（PIIG）（患者目标反应，PIGR），以及患者全球印象（PGI），在全面症状之后，通过最小的临床重要差异（MCID）管理（T7）。结果在本研究中分析了= 3患者= 3患者的三百九十七名患者。 T0和T7的PIIG的平均值分别为1.2（SD 1.5）和0.9（SD 1.4）。大多数患者（n = 406,89.8％）表示为T0的靶标的PIIG。 T7的这种靶标显着较低（P = <0.0005）。 PGI表达为MCID，被鉴于Insomnia强度的平均下降 - 2.3。在少数患者中（n = 26; 5.8％）失眠恶化，MCID为0.50（SD 2.8）。 T0的较高的失眠强度和T7在T7的低失血力强度与PGI独立相关。 PIGR在87.9％的患者中获得。 PIGR在T0处与PIIG相关联，并与T0和T7的失眠强度与T7处的PIIG逆转。结论PGIR和PGI似乎与评估失眠综合管理的影响，暗示了根据PIIG的治疗决策。已经检测到影响个体目标和临床反应的一些因素。

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