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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Acupuncture for cancer-related fatigue in lung cancer patients: a randomized, double blind, placebo-controlled pilot trial
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Acupuncture for cancer-related fatigue in lung cancer patients: a randomized, double blind, placebo-controlled pilot trial

机译：针灸肺癌患者癌症相关疲劳：随机，双盲，安慰剂控制的试验试验

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Abstract Background Cancer-related fatigue (CRF) is a distressing symptom that is the most common unpleasant side effect experienced by lung cancer patients and is challenging for clinical care workers to manage. Methods We performed a randomized, double-blind, placebo-controlled pilot trial to evaluate the clinical effect of acupuncture on CRF in lung cancer patients. Twenty-eight patients presenting with CRF were randomly assigned to active acupuncture or placebo acupuncture groups to receive acupoint stimulation (LI-4, Ren-6, St-36, KI-3, and Sp-6) twice per week for 4?weeks, followed by 2?weeks of follow-up. The primary outcome was the change in intensity of CFR based on the Chinese version of the Brief Fatigue Inventory (BFI-C). As the secondary endpoint, the Functional Assessment of Cancer Therapy-Lung Cancer Subscale (FACT-LCS) was adopted to assess the influence of acupuncture on patients’ quality of life (QOL). Adverse events and safety of treatments were monitored throughout the trial. Results Our pilot study demonstrated feasibility among patients with appropriate inclusion criteria and good compliance with acupuncture treatment. A significant reduction in the BFI-C score was observed at 2?weeks in the 14 participants who received active acupuncture compared with those receiving the placebo ( P ? P ? P ?=?0.002). There were no significant differences in the incidence of adverse events in either group ( P ?>?0.05). Conclusion Fatigue is a common symptom experienced by lung cancer patients. Acupuncture may be a safe and feasible optional method for adjunctive treatment in cancer palliative care, and appropriately powered trials are warranted to evaluate the effects of acupuncture.
机译：摘要背景癌症相关的疲劳（CRF）是一种令人痛苦的症状，是肺癌患者经历的最常见的令人不愉快的副作用，并对临床护理工作者进行挑战。方法采用随机，双盲，安慰剂控制的试验试验，以评估针灸对肺癌患者CRF的临床疗效。将28名患有CRF的患者随机分配给活性针灸或安慰剂针灸组，每周两次接受穴位刺激（LI-4，REN-6，ST-36，KI-3和SP-6），持续4个？ ，然后是2个星期的后续行动。主要结果是基于中文版的简短疲劳库存（BFI-C）的CFR强度变化。作为次要终点，采用癌症治疗 - 肺癌患者的功能评估（FACT-LCS）评估针灸对患者生活质量（QOL）的影响。在整个试验中监测治疗的不良事件和安全性。结果我们的试验研究表明，患者具有适当的纳入标准和良好遵守针灸治疗的患者之间的可行性。与接受安慰剂的人相比，在接受活性针灸的14个参与者中观察到BFI-C分数的显着减少（P？P？P？0.002）。任一组的不良事件发生率没有显着差异（p？> 0.05）。结论疲劳是肺癌患者经历的常见症状。针灸可能是癌症姑息治疗中的辅助治疗的安全可行的可选方法，并且需要适当的动力试验来评估针灸的影响。

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