...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Iron deficiency during first-line chemotherapy in metastatic cancers: a prospective epidemiological study
【24h】

Iron deficiency during first-line chemotherapy in metastatic cancers: a prospective epidemiological study

机译：转移性癌症一线化疗过程中的铁缺乏：前瞻性流行病学研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose Anemia is common in oncology and negatively impacts quality of life. However, there is lack of knowledge about iron deficiency (ID) epidemiology. The aim of this study was to prospectively assess iron status in patients with locally advanced or metastatic cancer beginning chemotherapy. Methods In this prospective, multicenter cohort study, anemia and ID were evaluated in patients with locally advanced or metastatic solid tumors and lymphoma before starting chemotherapy. Blood samples were collected at inclusion (W0), 6 weeks (W6), and 12 weeks (W12). Prevalence was evaluated in the general population, according to tumor location and was correlated with tumor response. Results One hundred twenty-nine patients were enrolled between 2013 and 2015; 119 had solid tumors and 10 lymphomas. At W0, there were no significant difference between locations with a prevalence around 50-60% (range 47.2-70.4%) and only a trend for colorectal cancer (70.4%, P = 0.069) due to a higher prevalence of absolute ID (18.5%). Prevalence of ID+ decreased between W0 and W6 and remained stable until W12 due to the proportion of patients with ID and without anemia. However, anemia prevalence increased during W0 and W6 and remained stable to W6 from W12 due to patients with anemia but without ID. A significant correlation between tumor response and ID prevalence was found (P = 0.036). Conclusions We confirm the high prevalence of ID and anemia in cancer patients. ID status is correlated to tumor response providing a strong rationale for iron monitoring during cancer management.
机译：目的贫血在肿瘤学中是常见的，对生活质量产生负面影响。但是，缺乏关于铁缺乏（ID）流行病学的知识。本研究的目的是在局部晚期或转移性癌症开始初期评估患者的熨斗状况。在本地先进或转移性实体肿瘤和淋巴瘤之前，评估了该前瞻性，多中心队列研究，贫血和ID的方法。在包含（W0），6周（W6）和12周（W12）的血液上收集血液样品。根据肿瘤位置，在一般人群中评估患病率，与肿瘤反应相关。结果2013年至2015年招收了一百二十九名患者; 119具有实体瘤和10个淋巴瘤。在W0，由于绝对ID的普遍性较高％）。 ID +的患病率在W0和W6之间减少，并且由于ID和不含贫血的患者的比例，直到W12保持稳定。然而，WO和W6期间贫血患病率增加，由于贫血患者，W12仍然稳定，由于贫血患者，但没有身份证。发现肿瘤反应与ID患病率之间的显着相关性（P = 0.036）。结论我们证实了癌症患者ID和贫血的高患病率。 ID状态与肿瘤响应相关，提供癌症管理期间的铁监测的强理由。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号