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Challenges in the Diagnosis of Gray Zone Lymphomas

机译:灰色区淋巴瘤诊断挑战

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The diagnosis of B-cell lymphoma unclassifi-able with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma, also called gray zone lymphoma (GZL), is frequently challenging. Incorrect diagnosis as either classic Hodgkin lymphoma or diffuse large B-cell lymphoma has significant implications for choice of upfront therapy based on recent large multi-institutional series from the United States and Europe. These studies have clarified some diagnostic challenges and provided guidance on the spectrum of morphologic features in this entity. This article clarifies some of the diagnostic conundrum surrounding GZL and provides an evidence-based approach to GZL diagnosis using morphology and immunohistochemistry.
机译:B细胞淋巴瘤的诊断unclassifi能够具有弥漫性大B细胞淋巴瘤和古典霍奇金淋巴瘤的中间体,也称为灰色区域淋巴瘤(GZL),经常具有挑战性。 作为经典霍奇金淋巴瘤或弥漫性大B细胞淋巴瘤的诊断不正确对基于来自美国和欧洲最近的大型多机构系列的前期治疗的选择具有显着影响。 这些研究阐明了一些诊断挑战,并为该实体的形态特征的光谱提供了指导。 本文阐明了GZL周围的一些诊断难题,并使用形态和免疫组化提供了一种基于循证的GZL诊断方法。

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