Human Papillomavirus-Independent Squamous Lesions of the Vulva

Jaclyn C. Watkins

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Human Papillomavirus-Independent Squamous Lesions of the Vulva

机译：外阴的人乳头瘤病毒无关鳞状病变

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The pathogenesis of vulvar squamous neoplasia has 2 pathways: human papillo-mavirus (HPV)-dependent and HPV-inde-pendent. The HPV-dependent pathway in the vulva follows the same progression as HPV-dependent lesions elsewhere in the gynecologic tract-HPV infection results in high-grade squamous intraepithelial lesion with subsequent progression to basaloid squamous cell carcinoma. The HPV-independent pathway is more complex, with a variety of precursor lesions and molecular alterations. Although the most recognized form of HPV-independent vulvar lesion is differentiated vulvar intraepithelial neoplasia, recent explorations have elucidated new precursors. This review provides an update on HPV-independent risk factors and precursor lesions for squamous cell carcinoma of the vulva.

机译：外阴鳞状肿瘤肿瘤肿瘤的发病机制具有2个途径：人乳头 - 群岛（HPV） - 依赖和HPV-INDE-PENDENT。外阴中的HPV依赖性途径遵循与妇科涉及的其他地方的HPV依赖性病变导致高级鳞状上皮内病变，随后对无碱鳞状细胞癌进行后续进展。 HPV的无关途径更复杂，具有各种前体病变和分子改变。虽然最公认的HPV无关的外阴病变是差异化外阴上皮内瘤形成的，但最近的探索阐述了新的前体。本综述提供了关于外阴鳞状细胞癌的HPV无关风险因子和前体病变的更新。

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《Surgical pathology clinics》 |2019年第2期|共13页
作者
Jaclyn C. Watkins;
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作者单位

Department of Pathology Microbiology and Immunology Vanderbilt University Medical;

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原文格式 PDF
正文语种 eng
中图分类病理学;
关键词
Verrucous carcinoma; Differentiated vulvar intraepithelial neoplasia; Vulvar acanthosis with altered differentiation; Vulvar dermatoses; Differentiated exophytic vulvar intraepithelial lesion;

机译：Verrucous Carcinoma;分化外阴上皮内瘤形成;不同分化改变的外阴刺痛;外阴皮肤病;分化的外阴外阴上皮病变;

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1. Human Papillomavirus-Independent Squamous Lesions of the Vulva [J] . Jaclyn C. Watkins Surgical pathology clinics . 2019,第2期

机译：外阴的人乳头瘤病毒无关鳞状病变
2. Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva [J] . Rakislova Natalia, Alemany Laia, Clavero Omar, American Journal of Surgical Pathology . 2018,第6期

机译：差异化外阴上皮内瘤状瘤类似物和LICHEN Sclerosus样病变在外阴相关鳞状细胞癌中
3. Premalignant and malignant squamous lesions of the vulva [J] . Maureen L Harmon Diagnostic histopathology . 2017,第1期

机译：外阴的前一种和恶性鳞状病变
4. Laser therapy as the method of choice in treating young women with CIN lesions of the uterine cervix and VIN lesions of the vulva [C] . Piotr A. Knapp, National Research Institute of Mother, Child, Lasers in Medicine . 1996

机译：激光疗法是治疗年轻妇女的宫颈CIN病变和外阴VIN病变的首选方法
5. BRAF gene status and the expression of growth factor signaling molecules in oral epithelial precursor lesions and squamous cell carcinoma [D] . TASHIRO KAZUKI 2019

机译：口腔上皮前体病变和鳞状细胞癌中BRAF基因的状态及生长因子信号分子的表达
6. p53 Immunohistochemical Patterns in HPV-Independent Squamous Cell Carcinomas of the Vulva and the Associated Skin Lesions: A Study of 779 Cases [O] . Natalia Rakislova, Laia Alemany, Omar Clavero, 2020

机译：P53免疫组化图案在外阴无关鳞状细胞癌和相关皮肤病患者：779例研究
7. Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva [O] . Natalia Rakislova, Laia Alemany, Omar Clavero, 2018

机译：差异化的外阴上皮内瘤状瘤状瘤类似物和Lichen Sclerosus样病变在外阴的HPV相关鳞状细胞癌中

Human Papillomavirus-Independent Squamous Lesions of the Vulva

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