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首页> 外文期刊>Sleep & breathing =: Schlaf & Atmung >The association between obstructive sleep apnea syndrome and metabolic syndrome: a confirmatory factor analysis
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The association between obstructive sleep apnea syndrome and metabolic syndrome: a confirmatory factor analysis

机译：阻塞性睡眠呼吸暂停综合征和代谢综合征之间的关联：验证因子分析

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摘要

Background Growing evidence suggests an independent relationship between obstructive sleep apnea syndrome (OSAS) and metabolic syndrome (MS). Patients with OSAS always show clustering of metabolic components. However, the understanding of interplay between OSAS and metabolic components is still lacking. Methods Participants were consecutively enrolled from our sleep center during the period 2009-2013. Anthropometric variables, metabolic indicators, and sleep parameters were collected from all participants. The factor structure for MS in OSAS and non-OSAS was examined by confirmatory factor analysis. Results The OSAS and non-OSAS demonstrated clustering of metabolic components. MS in patients with OSAS was strongly associated with insulin resistance (standardized factor loading = 0.93, p < 0.001), obesity (loading = 0.92, p < 0.001), and the lipid profile (loading = 0.72, p < 0.001). Furthermore, insulin resistance was correlated with obesity and lipid profile (r = 0.86, p < 0.001; r = 0.68, p < 0.001, respectively). Obesity and lipid profile were also highly correlated in OSAS (r = 0.66, p < 0.001). In non-OSAS, MS was strongly associated with insulin resistance, obesity, and lipid profile (loading = 0.95, p < 0.001; loading = 0.74, p < 0.001; loading = 0.68, p < 0.001, respectively). Insulin resistance was most strongly associated with fasting insulin (loading = 0.65, p < 0.001). Lipid profile was most strongly associated with TG (loading = 0.88, p < 0.001). Obesity was most strongly associated with BMI (loading = 0.80, p < 0.001). Conclusions OSAS is more prone to show clustering of metabolic components compared with non-OSAS. In particular, insulin resistance, obesity, and the lipid profile were independently and strongly correlated with MS in OSAS.
机译：背景技术日益增长的证据表明阻塞性睡眠呼吸暂停综合征（OSAS）和代谢综合征（MS）之间的独立关系。 OSA患者始终显示代谢组分的聚类。但是，仍然缺乏对OSA和代谢组件之间的相互作用的理解。方法在2009 - 2013年期间，参与者连续从我们的睡眠中心注册。从所有参与者收集人类测量变量，代谢指标和睡眠参数。通过验证因子分析检查了OSAS和非OSAs中MS的因子结构。结果OSA和非OSAS显示代谢组分的聚类。 OSA患者的MS与胰岛素抵抗力强烈相关（标准化因子载荷= 0.93，P <0.001），肥胖症（载入= 0.92，P <0.001）和脂质曲线（载入= 0.72，P <0.001）。此外，胰岛素抗性与肥胖和脂质曲线（r = 0.86，p <0.001; r = 0.68，p <0.001分别）相关。 OSAs（r = 0.66，p <0.001）中也具有高度相关性的肥胖和脂质谱。在非OSA中，MS与胰岛素抵抗，肥胖和脂质分布强烈相关（载入= 0.95，P <0.001; loading = 0.74，P <0.001分别）分别为0.68，p <0.001分别）。胰岛素抗性与空腹胰岛素最强烈相关（负载= 0.65，P <0.001）。脂质曲线与Tg最强烈的相关性（负载= 0.88，p <0.001）。肥胖与BMI最强烈相关（负载= 0.80，P <0.001）。结论与非OSA相比，OSAS更容易显示代谢组分的聚类。特别地，胰岛素抵抗，肥胖和脂质分布独立地，与OSAs中的MS强烈地相关。

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  • 来源
  • 作者

    Wang Fan; Xiong Xiaolu; Xu Huajun; Huang Hengye; Shi Yue; Li Xinyi; Qian Yingjun; Zou Jianyin; Yi Hongliang; Guan Jian; Yin Shankai;

  • 作者单位

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Otolaryngol Head &

    Neck Surg Yishan Rd;

    Nanjing Univ Sch Med Drum Tower Hosp Dept Endocrinol Nanjing 210008 Jiangsu Peoples R China;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Otolaryngol Head &

    Neck Surg Yishan Rd;

    Shanghai Jiao Tong Univ Dept Epidemiol Sch Publ Hlth 225 South Chongqing Rd Shanghai 200020;

    Shanghai Jiao Tong Univ Dept Epidemiol Sch Publ Hlth 225 South Chongqing Rd Shanghai 200020;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Otolaryngol Head &

    Neck Surg Yishan Rd;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Otolaryngol Head &

    Neck Surg Yishan Rd;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Otolaryngol Head &

    Neck Surg Yishan Rd;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Otolaryngol Head &

    Neck Surg Yishan Rd;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Otolaryngol Head &

    Neck Surg Yishan Rd;

    Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6 Dept Otolaryngol Head &

    Neck Surg Yishan Rd;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 呼吸系及胸部疾病;
  • 关键词

    Confirmatory factor analysis; Insulin resistance; Obesity; Obstructive sleep apnea syndrome; Metabolic syndrome;

    机译：确认因子分析;胰岛素抵抗;肥胖症;阻塞性睡眠呼吸暂停综合征;代谢综合征;

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