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首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Effects of Gabapentinoids Premedication on Shoulder Pain and Rehabilitation Quality after Laparoscopic Cholecystectomy: Pregabalin versus Gabapentin
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Effects of Gabapentinoids Premedication on Shoulder Pain and Rehabilitation Quality after Laparoscopic Cholecystectomy: Pregabalin versus Gabapentin

机译：甘蓝产素素对腹腔镜胆囊切除术后肩痛和康复质量的影响：普瑞巴林对甘彭素

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Introduction. Gabapentinoids are increasingly used in preoperative premedication despite controversial results. The aim of our study was to evaluate the effects of preemptive use of gabapentin or pregabalin on postoperative shoulder pain and rehabilitation quality after laparoscopic cholecystectomy. Methods. This is a clinical trial comparing the effects of a preoperative premedication with 600?mg of gabapentin or 150?mg of pregabalin versus placebo on postoperative pain and recovery quality after laparoscopic cholecystectomy. Premedication was taken 2 hours before the surgery beginning. Ninety patients were included and randomized into 3 groups (gabapentin, pregabalin, and placebo). The anesthetic protocol was the same for all patients. Primary endpoint was the shoulder pain intensity at the 48th postoperative hour. Secondary endpoints were postoperative nausea and vomiting (PONV), sleep quality during the first night, and the onset time for the first standing position. Results. During the first 48 postoperative hours, the gabapentin and pregabalin groups had significantly lower shoulder pain than the placebo group (p<0.05). In gabapentinoids groups, the incidence of PONV was lower and the sleep quality during the first postoperative night was better with significant results. Mean Spiegel scores were 22.43?±?1.45, 22.30?±?1.44, and 17.17?±?1.66, respectively, in pregabalin, gabapentin, and placebo groups (p<0.05). The delay for the first standing position was 14.9?±?4.9 hours in the pregabalin group, 9.7?±?3.6 hours in the gabapentin group, and 21.6?±?2.1 hours in the placebo group. No superiority was found between gabapentin and pregabalin. Conclusion. Preemptive premedication with gabapentinoids can enhance postoperative rehabilitation quality after laparoscopic cholecystectomy by reducing postoperative shoulder pain, decreasing PONV incidence, and improving sleep quality during the first postoperative night. This trial is registered with ClinicalTrial.gov (NCT03241875).
机译：介绍。尽管有争议的结果，但甘蓝产蛋白越来越多地用于术前预生。我们的研究目的是评估腹腔镜胆囊切除术后初始肩部疼痛和恢复质量的先发制用素或普瑞巴巴林的影响。方法。这是一种临床试验，比较术前预先用途的术前预先介绍的疗效，腹腔镜胆囊切除术后的术后疼痛和恢复品质的Prababentin或150μgαmg。在手术开始前2小时服用预留。将九十名患者纳入3组（加布帕顿，普瑞巴林和安慰剂）。所有患者的麻醉方案都是相同的。主要终点是术后第48小时的肩痛强度。次要终点是术后恶心和呕吐（PONV），第一晚的睡眠质量，以及第一站立位置的起始时间。结果。在术后48小时内，加巴佩顿和普瑞巴林基团比安慰剂组显着降低肩痛（P <0.05）。在甘蓝产蛋白组中，PONV的发病率降低，在第一个术后夜间的睡眠质量较好，具有显着的结果。平均Spiegel评分分别为22.43？±1.45,22.30？±1.44和17.17？±1.66，在Pragabalin，Gabapentin和安慰剂组中（P <0.05）。第一个站立位置的延迟为14.9？±4.9小时，在普瑞巴林组，9.7？±3.6小时，在加巴亨坦组和21.6？±2.1小时内。在加巴亨坦和普瑞巴林之间没有发现过优势。结论。通过降低术后肩痛，降低术后乳房疼痛，降低垂直肩部疼痛，腹腔镜胆囊切除术后，可以提高腹腔镜胆囊切除术后术后康复质量。此试验在ClinicalTrial.gov（NCT03241875）中注册。

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