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首页> 外文期刊>Parasitology >Endogenous development of Cystoisospora belli in intestinal and biliary epithelium of humans
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Endogenous development of Cystoisospora belli in intestinal and biliary epithelium of humans

机译：人类肠道胆管上皮细胞的内源性发展

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Cystoisospora (Isospora) belli is a coccidian parasite of humans. It can cause serious digestive disorders involving infection of intestines, biliary tract and gallbladder, especially in those with depressed immunity. It has a direct fecal–oral transmission cycle. After ingestion of sporulated oocysts, the parasite multiplies asexually and sexually within host epithelial cells, resulting in unsporulated oocysts that are excreted in feces. The details of asexual and sexual stages are not known and certain inclusions in epithelial cells in biopsy samples have been erroneously identified recently as C. belli. Here, we provide details of developmental stages of C. belli in two patients, in duodenal biopsy of one and biliary epithelium of the other. Immature and mature asexual stages (schizonts/meronts) were seen in epithelial cells. The merozoites were seen singly, in pairs and in groups in single parasitophorous vacuole (pv) in host cytoplasm. Immature and mature meronts were seen together in the same pv; up to eight nuclei were seen in meronts that retained elongated crescent shape; round multinucleated schizonts, seen in other coccidians, were not found. Meronts were up to 25 μm long and contained up to ten merozoites that were 8–11 μm long. The merozoites and meronts contained PAS-positive granules. Microgamonts (male) contained up to 30 nuclei that were arranged at the periphery and had condensed chromatin; 1–3 PAS-positive, eosinophilic, residual bodies were left when microgametes were formed. The microgametes were 4 μm long and PAS-negative. All stages of macrogamonts, including oocysts were PAS-positive. The detailed description of the life cycle stages of C. belli reported here should facilitate in histopathologic diagnosis of this parasite.
机译：膀胱孢子孢子（Isospora）Belli是人类的孢子座寄生虫。它会导致涉及感染肠道，胆道和胆囊的严重消化障碍，特别是在患有免疫抑郁的人中。它具有直接的粪便口腔传输周期。在摄入孢子形卵囊后，寄生虫在宿主上皮细胞内无性和性，导致在粪便中排出的令人浓郁的卵囊。无性和性阶段的细节未知，并且最近在活组织检查样品中的上皮细胞中的某些夹杂物被错误地鉴定为C. Belli。在这里，我们在两名患者中提供了两名患者的C.Belli的发育阶段的细节，在另一种和胆道上皮的十二指肠活组织检查中。在上皮细胞中看到未成熟和成熟的无性阶段（Schizonts / Milonts）。单独，在宿主细胞质中单独地，成对和在单一吸引液（PV）中单独地看到。在相同的光伏中均匀地看到不成熟和成熟的Muntons;在与绵延新月形形状保留的Meronts中，最多可见八个核;没有找到圆形的多核精神分道，在其他鸽子中看到，没有找到。 Munonts长达25μm长，含有最多10个Merozoites，长度为8-11μm。 Merozoites和Meronts含有PAS阳性颗粒。微晕（男性）含有最多30个核，其布置在周边并凝结染色质;在形成微磁性时，留下1-3 pas-阳性，嗜酸性，残留的残留体。微磁性少量为4μm长而PAS阴性。所有巨大的宏观神经阶段，包括卵囊都是PAS阳性的。在此报告的C.Belli的生命周期阶段的详细描述应促进该寄生虫的组织病理学诊断。

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