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Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution

机译:促葡萄球菌研究的最新进展:基因组组织,表达,新陈代谢,分类和进化

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摘要

Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number of diseases in humans, domestic animals and plants. Their monoxenous relatives are restricted to insects. Because of the high biological diversity, adaptability to dramatically different environmental conditions, and omnipresence, these protists have major impact on all biotic communities that still needs to be fully elucidated. In addition, as these organisms represent a highly divergent evolutionary lineage, they are strikingly different from the common ‘model system’ eukaryotes, such as some mammals, plants or fungi. A number of excellent reviews, published over the past decade, were dedicated to specialized topics from the areas of trypanosomatid molecular and cell biology, biochemistry, host–parasite relationships or other aspects of these fascinating organisms. However, there is a need for a more comprehensive review that summarizing recent advances in the studies of trypanosomatids in the last 30 years, a task, which we tried to accomplish with the current paper.
机译:家庭胰蛋白酶的单细胞鞭毛是无脊椎动物,脊椎动物和植物的强制寄生虫。掺锡物种是人类,家畜和植物中许多疾病的疾病。他们的一元亲属被限制为昆虫。由于生物多样性高,适应性急剧不同的环境条件和无所不在,这些保护者对所有仍然需要完全阐明的生物社区产生重大影响。此外,由于这些生物代表了高度发散的进化谱系,它们与普通的“模型系统”真核生物不同,例如一些哺乳动物,植物或真菌。在过去十年中发表的一些优秀的评论致力于从替蓬松瘤瘤分子和细胞生物学,生物化学,宿主寄生虫关系或这些迷人的生物的其他方面的专门主题。然而,需要更全面的审查,总结过去30年中锥虫炎的研究的最新进展,这是我们试图通过目前纸张完成的任务。

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