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The resistance against Trichinella spiralis infection induced by primary infection with respiratory syncytial virus

机译：用呼吸道合胞病毒原发性感染诱导的Trichinella Spiralis感染的抵抗力

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Human infections with Trichinella spiralis and respiratory syncytial virus (RSV) are common, as T. spiralis infections are re-emerging in various parts of the world and RSV infections remain a threat for infants. Yet, studies investigating the relationship pertaining to the two are severely lacking. In particular, immune response induction via RSV and T. spiralis remain largely elusive. Here, we investigated the resistance against T. spiralis infection induced upon primary infection with RSV. RSV, notorious for causing severe inflammatory reaction in the lungs, were intranasally infected, followed with a T. spiralis infection in mice. Our results revealed that primary RSV infection in mice significantly raised T. spiralis-specific and total IgE, IgG and its subclass antibody responses upon T. spiralis challenge infection (RSV-Ts). Blood eosinophil levels were decreased in RSV-Ts, accompanied with significant increase in both Th1 and Th2 cytokines. Antibodies generated against RSV in RSV-infected mice were found to react with T. spiralis excretory/secretory antigen, showing several bands determined through immunoblotting. RSV-Ts also had a marked reduction of T. spiralis worm burden in diaphragm. These results indicate that immune responses induced by RSV infection contribute to resistance against subsequent T. spiralis infection.
机译：用Trichinella spiralis和呼吸道同性恋病毒（RSV）的人类感染是常见的，因为T.Spiralis感染在世界各地重新出现，而RSV感染仍然是婴儿的威胁。然而，调查与两者有关的关系的研究受到严重缺乏。特别地，通过RSV和T. Spiralis的免疫应答诱导仍然很大程度上是难以捉摸的。在这里，我们研究了对RSV原发性感染诱导的诱导T.Tavalis感染的抵抗力。 RSV，在肺部造成严重的炎症反应臭名昭着，鼻内感染，在小鼠中进行了T. spiralis感染。我们的研究结果表明，小鼠的主要RSV感染显着升高了螺旋螺旋螺旋螺旋状和总IgE，IgG及其亚类抗体反应在T. spiralis攻击感染（RSV-TS）。 RSV-TS血液嗜酸性粒细胞水平降低，伴随着TH1和TH2细胞因子的显着增加。发现针对RSV感染的小鼠中产生的RSV产生的抗体与T. spiralis排泄/分泌抗原反应，显示通过免疫印迹确定的几个条带。 RSV-TS也有明显减少了膈肌的螺旋蠕虫负担。这些结果表明，RSV感染诱导的免疫应答有助于抵抗随后的T.螺旋感染。

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