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首页> 外文期刊>Parasitology >Diversity of extracellular proteins during the transition from the 'proto-apicomplexan' alveolates to the apicomplexan obligate parasites
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Diversity of extracellular proteins during the transition from the 'proto-apicomplexan' alveolates to the apicomplexan obligate parasites

机译：从“原始ApiCoMplex”肺泡到Apicomplexan的过渡期间细胞外蛋白的多样性

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摘要

The recent completion of high-coverage draft genome sequences for several alveolate protozoans - namely, the chromerids, Chromera velia and Vitrella brassicaformis; the perkinsid Perkinsus marinus; the apicomplexan, Gregarina niphandrodes, as well as high coverage transcriptome sequence information for several colpodellids, allows for new genome-scale comparisons across a rich landscape of apicomplexans and other alveolates. Genome annotations can now be used to help interpret fine ultrastructure and cell biology, and guide new studies to describe a variety of alveolate life strategies, such as symbiosis or free living, predation, and obligate intracellular parasitism, as well to provide foundations to dissect the evolutionary transitions between these niches. This review focuses on the attempt to identify extracellular proteins which might mediate the physical interface of cell-cell interactions within the above life strategies, aided by annotation of the repertoires of predicted surface and secreted proteins encoded within alveolate genomes. In particular, we discuss what descriptions of the predicted extracellular proteomes reveal regarding a hypothetical last common ancestor of a pre-apicomplexan alveolate - guided by ultrastructure, life strategies and phylogenetic relationships - in an attempt to understand the evolution of obligate parasitism in apicomplexans.
机译：最近完成几种肺泡原生动物的高覆盖草案基因组序列 - 即染色体，染色体柔性柔毛和Vitrella Brassicafis; perkinsid perkinsus marinus;对于几种ColpodellID，ApiCoMplexan，Gregarina Niphandrode以及高覆盖转录组序列信息，允许通过富含ApiCoMemplean和其他肺泡的富景观的新的基因组规模比较。基因组注释现在可以用来帮助解释细微的超微结构和细胞生物学，并指导新的研究来描述各种肺泡生命策略，例如共生或自由生活，捕食，并使细胞内寄生作用，并提供对剖析的基础这些利基之间的进化过渡。该综述侧重于试图鉴定可能在上述寿命策略内介导细胞 - 细胞相互作用物理界面的细胞外蛋白，并通过注释预测表面和分泌蛋白质在肺泡基因组内的分泌蛋白质的注释来辅助。特别是，我们讨论了预测的细胞外蛋白质群的描述揭示了关于预艾基莫昔单抗的假设的最后共同祖先 - 以超微结构，寿命策略和系统发育关系引导 - 以试图了解ApiCoMplex人类中的寄生寄生症的演变。

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