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首页> 外文期刊>Parasitology >Diversity of extracellular proteins during the transition from the 'proto-apicomplexan' alveolates to the apicomplexan obligate parasites
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Diversity of extracellular proteins during the transition from the 'proto-apicomplexan' alveolates to the apicomplexan obligate parasites

机译：从“原始apicomplexan”肺泡向apicomplexan专性寄生虫过渡期间细胞外蛋白的多样性

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摘要

The recent completion of high-coverage draft genome sequences for several alveolate protozoans - namely, the chromerids, Chromera velia and Vitrella brassicaformis; the perkinsid Perkinsus marinus; the apicomplexan, Gregarina niphandrodes, as well as high coverage transcriptome sequence information for several colpodellids, allows for new genome-scale comparisons across a rich landscape of apicomplexans and other alveolates. Genome annotations can now be used to help interpret fine ultrastructure and cell biology, and guide new studies to describe a variety of alveolate life strategies, such as symbiosis or free living, predation, and obligate intracellular parasitism, as well to provide foundations to dissect the evolutionary transitions between these niches. This review focuses on the attempt to identify extracellular proteins which might mediate the physical interface of cell-cell interactions within the above life strategies, aided by annotation of the repertoires of predicted surface and secreted proteins encoded within alveolate genomes. In particular, we discuss what descriptions of the predicted extracellular proteomes reveal regarding a hypothetical last common ancestor of a pre-apicomplexan alveolate - guided by ultrastructure, life strategies and phylogenetic relationships - in an attempt to understand the evolution of obligate parasitism in apicomplexans.
机译：最近完成了几种肺泡原生动物的高覆盖度基因组草图序列，即chrome虫，Chromera velia和芸苔Vitrella; Perkinsid Perkinsus marinus; apicomplexan，Gregarina niphandrodes以及几种秋蓬鱼的高覆盖转录组序列信息，可以在apicomplexans和其他肺泡的丰富景观中进行新的基因组规模比较。基因组注释现在可用于帮助解释精细的超微结构和细胞生物学，并指导新的研究描述各种肺泡的生活策略，例如共生或自由生活，捕食和专性细胞内寄生，并为解剖昆虫提供基础。这些利基之间的进化过渡。这篇综述着重于尝试鉴定可能介导上述生命策略内的细胞-细胞相互作用的物理界面的细胞外蛋白质，并通过注释在肺泡基因组内编码的预测表面和分泌蛋白质的组成部分。特别是，我们讨论了关于超复合物，生活策略和系统发育关系的指导下，前复合体肺泡的假想的最后共同祖先揭示了哪些预测的细胞外蛋白质组的描述，以试图了解复合体中专性寄生虫的进化。

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