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首页> 外文期刊>Parasitology >Nerolidol, the main constituent of Piper aduncum essential oil, has anti-Leishmania braziliensis activity
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Nerolidol, the main constituent of Piper aduncum essential oil, has anti-Leishmania braziliensis activity

机译：Nerolidol，吹笛者Aduncum精油的主要成分，具有抗Leishmania Braziliensis活性

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摘要

Leishmania (Viannia) braziliensis is a protozoan that causes mucocutaneous leishmaniasis, which is an infectious disease that affects more than 12 million people worldwide. The available treatment is limited, has side-effects or is inefficient. In a search for alternative compounds of natural origin, we tested the microbicidal activity of Piper aduncum essential oil (PaEO) on this parasite. Our data showed that PaEO had an inhibitory effect on the growth of L. braziliensis promastigotes with an IC50/24 h= 77.9 mu g mL(-1). The main constituent (nerolidol: 25.22%) presented a similar inhibitory effect (IC50/24 h = 74.3 mu g mL(-1)). Ultrastructural observation of nerolidol-treated parasites by scanning and transmission electron microscopies revealed cell shrinkage and morphological alterations in the mitochondrion, nuclear chromatin and flagellar pocket. Flow cytometry analysis showed a reduction in the cell size, loss of mitochondrial membrane potential, phosphatidylserine exposure and DNA degradation, which when associated with the morphological changes indicated that nerolidol induced incidental cell death in the L. braziliensis promastigotes. The results presented here indicate that nerolidol derivatives are promising compounds for further evaluation against Leishmania parasites.
机译：Leishmania（Viannia）巴西是一种原因，导致霉菌利什曼病，这是一种影响全世界超过1200万人的传染病。可用的处理有限，具有副作用或效率低下。在寻找自然来源的替代化合物中，我们在该寄生虫上测试了吹笛子残疾物精油（Paeo）的微生物活性。我们的数据表明，Paeo对L.Braziliensis Promastigotes的抑制作用，IC50 / 24h =77.9μg（-1）。主要成分（Nerolidol：25.22％）呈现出类似的抑制作用（IC50 / 24h =74.3μgml（-1））。扫描和透射电子显微镜通过扫描和透射电子显微镜的超微结构观察显示细胞收缩和线粒体，核染色质和鞭毛袋中的形态改变。流式细胞术分析显示细胞尺寸，线粒体膜电位，磷脂酰丝氨酸暴露和DNA降解的损失，这在与形态学变化相关时表明Nerolidol在L.Braziliensis Promastigotes中诱导偶然细胞死亡。此处提出的结果表明，野生酚衍生物是有前途的化合物，用于进一步评估Leishmania寄生虫。

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