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首页> 外文期刊>Parasitology >Vesicle trafficking during sporozoite development in Plasmodium berghei: ultrastructural evidence for a novel trafficking mechanism
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Vesicle trafficking during sporozoite development in Plasmodium berghei: ultrastructural evidence for a novel trafficking mechanism

机译：Plasmodium Perghei中孢子生成发育期间的囊泡贩运：新型贩运机制的超微结构证据

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摘要

Oocysts from Anopheles Stephens! mosquitoes fed on murine blood infected with Plasmodium berghei berghei, were fixed for electron microscopy 6-12 days post-feeding. Ultrastructural analysis focused on Golgi-related trafficking pathways for rhoptry and microneme formation during sporogony. A small Golgi complex of 1-3 cisternae is formed close to the spindle pole body from coated vesicles budded from the nuclear envelope which is confluent with the endoplasmic reticulum. Rhoptries begin as small spheroidal bodies apparently formed by fusion of Golgi-derived vesicles, lengthening to 3-4 /mi, and increasing in number to 4 per sporozoite. Ultrastructural data indicate the presence of a novel mechanism for vesicle transport between the Golgi complex and rhoptries along a longitudinal 30 nm - thick fibre (rootlet fibre or tigelle). Filamentous links between vesicles and rootlet indicate that this is a previously undescribed vesicle transport organelle. Genesis of micronemes occurs late in bud maturation and starts as spheroidal dense-cored vesicles (pro-micronemes), transforming to their mature bottle-like shape as they move apically. Filamentous links also occur between micronemes and subpellicular microtubules, indicating that as in merozoites, micronemes are trafficked actively along these structures.
机译：来自Anopheles Stephens的卵囊！蚊子喂养鼠血液感染宠物贝尔赫氏疟原虫的血液，针对电子显微镜检查6-12天后固定。超微结构分析专注于孢子术期间的高尔基相关贩运途径。 1-3个CISTernae的小Golgi复合物形成靠近从核心囊孔的涂布囊泡的主轴杆体形成，该核封套与内质网汇合。革命开始作为明显通过融合Golgi衍生的囊泡，延长至3-4 / mi的小球体，并且每孢子的数量增加至4。超微结构数据表明沿纵向30nm厚的纤维（根纤维或Tigelle）的高尔基复合物和革命之间的囊泡输送的新机制。囊泡和根部之间的丝状环节表明这是先前未描述的囊泡运输细胞器。微粒的成因发生在芽成熟晚期，并以球形致密粘膜（Pro-Micronemes）开始，在顶部移动时转化为其成熟的瓶状形状。丝状链接也发生在微量阳细胞和亚粒细胞微管之间，表明如在Merozoites中，微孔沿着这些结构主动被贩运。

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