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首页> 外文期刊>Parasitology >Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi
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Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi

机译：碳酸钙中苯并唑的纳米淀粉增加了对锥虫瘤的选择性克鲁齐

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摘要

Chagas disease is a public health problem, affecting about 7 million people worldwide. Benznidazole (BZN) is the main treatment option, but it has limited effectiveness and can cause severe adverse effects. Drug delivery through nanoparticles has attracted the interest of the scientific community aiming to improve therapeutic options. The aim of this study was to evaluate the cytotoxicity of benznidazole-loaded calcium carbonate nanoparticles (BZN@CaCO3) on Trypanosoma cruzi strain Y. It was observed that BZN@CaCO3 was able to reduce the viability of epimastigote, trypomastigote and amastigote forms of T. cruzi with greater potency when compared with BZN. The amount of BZN necessary to obtain the same effect was up to 25 times smaller when loaded with CaCO3 nanoparticles. Also, it was observed that BZN@CaCO3 enhanced the selectivity index. Furthermore, the cell-death mechanism induced by both BZN and BZN@CaCO3 was evaluated, indicating that both substances caused necrosis and changed mitochondrial membrane potential.
机译：Chagas疾病是一个公共卫生问题，影响全世界约700万人。 Benznidazole（BZN）是主要的治疗方法，但有限的有效性，并且会导致严重的不利影响。通过纳米颗粒的药物递送吸引了科学界的利益，旨在改善治疗方案。本研究的目的是评估苯并咪唑加载碳酸钙纳米粒子（BZN @ CaCO3）的细胞毒性在锥虫瘤Cruzi菌株Y中。观察到BZN @ Caco3能够降低ePimastigotoot，Tropopomastigote和Amastigoto形式的生存力。与BZN相比，Cruzi具有更大的效力。在用CaCO 3纳米颗粒加载时，获得相同效果所需的BZN的量高达25倍。此外，观察到BZN @ Caco3增强了选择性指数。此外，评价BZN和BZN @ Caco3诱导的细胞死亡机制，表明两种物质导致坏死和改变线粒体膜电位。

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