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首页> 外文期刊>Pakistan Veterinary Journal >Variation in the Genetic Effects of ABCG2, Growth Hormone and Growth Hormone Receptor Gene Polymorphisms on Milk Production Traits in Egyptian Native, Holstein and Hybrid Cattle Populations
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Variation in the Genetic Effects of ABCG2, Growth Hormone and Growth Hormone Receptor Gene Polymorphisms on Milk Production Traits in Egyptian Native, Holstein and Hybrid Cattle Populations

机译：ABCG2，生长激素和生长激素受体基因多态性对埃及天然，荷斯坦和杂交牛群牛奶生产性状的遗传效应的变异

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The aim of the present study was to evaluate the effect of polymorphisms in the ATP-binding cassette subfamily G member 2 (ABCG2), growth hormone (GH) and growth hormone receptor (GHR) genes on 305-day yields and milk traits in native Egyptian cattle (Baladi), Holstein Friesian cattle and hybrid cattle using DNA sequencing and Restriction Fragment Length Polymorphisms (RFLPs). A total of 148 cows were selected from the three animal populations. The ABCG2-HhaI-AA genotype was significantly associated with an increased milk lactose percentage and reduced milk yields in Baladi cows. The GH-MSPI-heterozygous genotype (GH) showed significant associations with SNF, protein and lactose percentages in the hybrid cows. Fewer TG repeats were found in the 5' untranslated region of GHR in Baladi cows, which could be used for marker-assisted selection to protect against the lower milk yields observed in this population. Additionally, GHR-MSPI-VL, can be associated with higher SNF, fat, protein and lactose percentages in hybrid cows, as well as lower milk yields in Baladi cows. We concluded that the three cattle populations have their own genetic identities in relation to genetic markers, which can be used for marker-assisted selection to improve milk traits in these three cattle populations. (C) 2018 PVJ. All rights reserved
机译：本研究的目的是在305天的产量和乳状物质中评估多态性在ATP结合盒亚家族G成员2（ABCG2），生长激素（GH）和生长激素受体（GHR）基因中的多态性的影响埃及牛（Baladi），Holstein Friesian牛和杂交牛采用DNA测序和限制片段长度多态性（RFLP）。从三个动物种群中选择了148个奶牛。 ABCG2-Hai-AA基因型与乳乳糖率增加显着相关，并在Baladi奶牛中减少牛奶率。 GH-MSPI-杂合子基因型（GH）显示出与杂交奶牛中的SNF，蛋白质和乳糖百分比的显着关联。在Baladi奶牛的5'未翻译区域中发现了更少的TG重复，可用于标记辅助选择以防止在该群体中观察到的较低的牛奶产率。此外，GHR-MSPI-VL，可以与杂交奶牛中的较高的SNF，脂肪，蛋白质和乳糖百分比相关，以及Baladi奶牛的较低奶产生。我们得出结论，三个牛群具有与遗传标志物相关的遗传标志，可用于标记辅助选择，以改善这三个牛群中的牛奶特征。 （c）2018 PVJ。版权所有

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